Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1098393..1098985 Replicon chromosome
Accession NZ_CP090967
Organism Edwardsiella piscicida strain KE5

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag L1P07_RS04935 Protein ID WP_012847872.1
Coordinates 1098393..1098596 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D0ZEC3
Locus tag L1P07_RS04940 Protein ID WP_012847873.1
Coordinates 1098617..1098985 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P07_RS04905 (L1P07_04905) 1094126..1094587 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
L1P07_RS04910 (L1P07_04910) 1094892..1095230 + 339 WP_012847867.1 P-II family nitrogen regulator -
L1P07_RS04915 (L1P07_04915) 1095252..1096532 + 1281 WP_041692495.1 ammonium transporter AmtB -
L1P07_RS04920 (L1P07_04920) 1096567..1097433 - 867 WP_012847869.1 acyl-CoA thioesterase II -
L1P07_RS04925 (L1P07_04925) 1097542..1097871 - 330 WP_225857588.1 MGMT family protein -
L1P07_RS04935 (L1P07_04935) 1098393..1098596 - 204 WP_012847872.1 HHA domain-containing protein Toxin
L1P07_RS04940 (L1P07_04940) 1098617..1098985 - 369 WP_012847873.1 Hha toxicity modulator TomB Antitoxin
L1P07_RS04945 (L1P07_04945) 1099353..1102505 - 3153 WP_012847874.1 efflux RND transporter permease subunit -
L1P07_RS04950 (L1P07_04950) 1102549..1103733 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T232238 WP_012847872.1 NZ_CP090967:c1098596-1098393 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T232238 NZ_CP127274:c3120897-3120505 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14129.83 Da        Isoelectric Point: 6.1484

>AT232238 WP_012847873.1 NZ_CP090967:c1098985-1098617 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNATLHV

Download         Length: 369 bp

>AT232238 NZ_CP127274:c3121109-3120894 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB D0ZEC3

References