Detailed information of TA system TA232234

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3178894..3179557
• Replicon: chromosome
• Accession: NZ_CP090962
• Organism: Edwardsiella piscicida strain CZ12001

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L1P06_RS14600
• Protein ID: WP_041692803.1
• Coordinates: 3178894..3179310 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: L1P06_RS14605
• Protein ID: WP_012849755.1
• Coordinates: 3179291..3179557 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1P06_RS14580 (L1P06_14580)	3174825..3176558	-	1734	WP_015462273.1	single-stranded-DNA-specific exonuclease RecJ	-
L1P06_RS14585 (L1P06_14585)	3176563..3177279	-	717	WP_015462274.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
L1P06_RS14590 (L1P06_14590)	3177307..3178206	-	900	WP_015462275.1	site-specific tyrosine recombinase XerD	-
L1P06_RS14595 (L1P06_14595)	3178357..3178869	+	513	WP_012849753.1	flavodoxin FldB	-
L1P06_RS14600 (L1P06_14600)	3178894..3179310	-	417	WP_041692803.1	protein YgfX	Toxin
L1P06_RS14605 (L1P06_14605)	3179291..3179557	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
L1P06_RS14610 (L1P06_14610)	3179905..3180903	+	999	WP_015462277.1	tRNA-modifying protein YgfZ	-
L1P06_RS14615 (L1P06_14615)	3180946..3181770	-	825	WP_015462278.1	shikimate 5-dehydrogenase	-
L1P06_RS14620 (L1P06_14620)	3181929..3182801	-	873	WP_012849758.1	nucleoside-specific channel-forming protein Tsx	-
L1P06_RS14625 (L1P06_14625)	3183410..3184060	+	651	WP_015462279.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16243.06 Da
• Isoelectric Point: 11.6049

>T232234 WP_041692803.1 NZ_CP090962:c3179310-3178894 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGTLVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Nucleotide

• Length: 417 bp

>T232234 NZ_CP127274:c3054520-3054104 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT232234 WP_012849755.1 NZ_CP090962:c3179557-3179291 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT232234 NZ_CP127274:c3054783-3054517 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8