Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1093988..1094580 Replicon chromosome
Accession NZ_CP090962
Organism Edwardsiella piscicida strain CZ12001

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag L1P06_RS04885 Protein ID WP_012847872.1
Coordinates 1093988..1094191 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag L1P06_RS04890 Protein ID WP_015461125.1
Coordinates 1094212..1094580 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P06_RS04855 (L1P06_04855) 1089671..1090132 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
L1P06_RS04860 (L1P06_04860) 1090437..1090775 + 339 WP_012847867.1 P-II family nitrogen regulator -
L1P06_RS04865 (L1P06_04865) 1090797..1092077 + 1281 WP_041692495.1 ammonium transporter AmtB -
L1P06_RS04870 (L1P06_04870) 1092112..1092978 - 867 WP_012847869.1 acyl-CoA thioesterase II -
L1P06_RS04875 (L1P06_04875) 1093088..1093417 - 330 WP_225857588.1 MGMT family protein -
L1P06_RS04885 (L1P06_04885) 1093988..1094191 - 204 WP_012847872.1 HHA domain-containing protein Toxin
L1P06_RS04890 (L1P06_04890) 1094212..1094580 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
L1P06_RS04895 (L1P06_04895) 1094948..1098100 - 3153 WP_012847874.1 efflux RND transporter permease subunit -
L1P06_RS04900 (L1P06_04900) 1098144..1099328 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T232225 WP_012847872.1 NZ_CP090962:c1094191-1093988 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T232225 NZ_CP127274:c2348454-2348020 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT232225 WP_015461125.1 NZ_CP090962:c1094580-1094212 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT232225 NZ_CP127274:c2348715-2348461 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References