Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 3547736..3548264 | Replicon | chromosome |
Accession | NZ_CP090959 | ||
Organism | Simiduia sp. 21SJ11W-1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | L1F30_RS15625 | Protein ID | WP_253357638.1 |
Coordinates | 3547974..3548264 (+) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | L1F30_RS15620 | Protein ID | WP_253357636.1 |
Coordinates | 3547736..3547984 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L1F30_RS15580 (L1F30_15580) | 3543280..3543675 | - | 396 | WP_253357618.1 | MmcQ/YjbR family DNA-binding protein | - |
L1F30_RS15585 (L1F30_15585) | 3543897..3544148 | + | 252 | WP_253357620.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
L1F30_RS15590 (L1F30_15590) | 3544145..3544405 | + | 261 | WP_253357622.1 | Txe/YoeB family addiction module toxin | - |
L1F30_RS15595 (L1F30_15595) | 3544474..3544932 | - | 459 | WP_253357630.1 | hypothetical protein | - |
L1F30_RS15600 (L1F30_15600) | 3545357..3545638 | - | 282 | WP_253356743.1 | hypothetical protein | - |
L1F30_RS15605 (L1F30_15605) | 3545751..3546206 | - | 456 | WP_253357632.1 | lysozyme inhibitor LprI family protein | - |
L1F30_RS15610 (L1F30_15610) | 3546661..3547119 | - | 459 | WP_253356246.1 | DUF2310 family Zn-ribbon-containing protein | - |
L1F30_RS15615 (L1F30_15615) | 3547261..3547539 | - | 279 | WP_253357634.1 | hypothetical protein | - |
L1F30_RS15620 (L1F30_15620) | 3547736..3547984 | + | 249 | WP_253357636.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
L1F30_RS15625 (L1F30_15625) | 3547974..3548264 | + | 291 | WP_253357638.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
L1F30_RS15630 (L1F30_15630) | 3548373..3548654 | - | 282 | WP_253357640.1 | hypothetical protein | - |
L1F30_RS15635 (L1F30_15635) | 3548740..3549225 | - | 486 | WP_253357642.1 | hypothetical protein | - |
L1F30_RS15640 (L1F30_15640) | 3551479..3551829 | - | 351 | WP_253357644.1 | hypothetical protein | - |
L1F30_RS15645 (L1F30_15645) | 3551955..3552215 | - | 261 | WP_253357646.1 | hypothetical protein | - |
L1F30_RS15650 (L1F30_15650) | 3552812..3553192 | - | 381 | WP_253357648.1 | VOC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 3545751..3555426 | 9675 | |
- | inside | Integron | - | - | 3544940..3555426 | 10486 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11107.99 Da Isoelectric Point: 10.6516
>T232224 WP_253357638.1 NZ_CP090959:3547974-3548264 [Simiduia sp. 21SJ11W-1]
MTYNLEFKKSALKEWKKLNPSVRDIFKKKLAERLETPHVPASAIRGGKNLYKIKLRQLGYRLVYSVTDSTITVTVLVVGK
RNRNEVYDLALSRDEP
MTYNLEFKKSALKEWKKLNPSVRDIFKKKLAERLETPHVPASAIRGGKNLYKIKLRQLGYRLVYSVTDSTITVTVLVVGK
RNRNEVYDLALSRDEP
Download Length: 291 bp
>T232224 NZ_CP127274:2304991-2305401 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9152.66 Da Isoelectric Point: 4.3228
>AT232224 WP_253357636.1 NZ_CP090959:3547736-3547984 [Simiduia sp. 21SJ11W-1]
VAYQILTEMAASISELKANPMKVVSSGEGMPIAVLNRNEPAFYCIPAKAYEAMINLIEDKELLEIVRARIDEESIKVRLD
DL
VAYQILTEMAASISELKANPMKVVSSGEGMPIAVLNRNEPAFYCIPAKAYEAMINLIEDKELLEIVRARIDEESIKVRLD
DL
Download Length: 249 bp
>AT232224 NZ_CP127274:2304765-2304998 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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