Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3547736..3548264 Replicon chromosome
Accession NZ_CP090959
Organism Simiduia sp. 21SJ11W-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L1F30_RS15625 Protein ID WP_253357638.1
Coordinates 3547974..3548264 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L1F30_RS15620 Protein ID WP_253357636.1
Coordinates 3547736..3547984 (+) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F30_RS15580 (L1F30_15580) 3543280..3543675 - 396 WP_253357618.1 MmcQ/YjbR family DNA-binding protein -
L1F30_RS15585 (L1F30_15585) 3543897..3544148 + 252 WP_253357620.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
L1F30_RS15590 (L1F30_15590) 3544145..3544405 + 261 WP_253357622.1 Txe/YoeB family addiction module toxin -
L1F30_RS15595 (L1F30_15595) 3544474..3544932 - 459 WP_253357630.1 hypothetical protein -
L1F30_RS15600 (L1F30_15600) 3545357..3545638 - 282 WP_253356743.1 hypothetical protein -
L1F30_RS15605 (L1F30_15605) 3545751..3546206 - 456 WP_253357632.1 lysozyme inhibitor LprI family protein -
L1F30_RS15610 (L1F30_15610) 3546661..3547119 - 459 WP_253356246.1 DUF2310 family Zn-ribbon-containing protein -
L1F30_RS15615 (L1F30_15615) 3547261..3547539 - 279 WP_253357634.1 hypothetical protein -
L1F30_RS15620 (L1F30_15620) 3547736..3547984 + 249 WP_253357636.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L1F30_RS15625 (L1F30_15625) 3547974..3548264 + 291 WP_253357638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1F30_RS15630 (L1F30_15630) 3548373..3548654 - 282 WP_253357640.1 hypothetical protein -
L1F30_RS15635 (L1F30_15635) 3548740..3549225 - 486 WP_253357642.1 hypothetical protein -
L1F30_RS15640 (L1F30_15640) 3551479..3551829 - 351 WP_253357644.1 hypothetical protein -
L1F30_RS15645 (L1F30_15645) 3551955..3552215 - 261 WP_253357646.1 hypothetical protein -
L1F30_RS15650 (L1F30_15650) 3552812..3553192 - 381 WP_253357648.1 VOC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3545751..3555426 9675
- inside Integron - - 3544940..3555426 10486


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-84)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11107.99 Da        Isoelectric Point: 10.6516

>T232224 WP_253357638.1 NZ_CP090959:3547974-3548264 [Simiduia sp. 21SJ11W-1]
MTYNLEFKKSALKEWKKLNPSVRDIFKKKLAERLETPHVPASAIRGGKNLYKIKLRQLGYRLVYSVTDSTITVTVLVVGK
RNRNEVYDLALSRDEP

Download         Length: 291 bp

>T232224 NZ_CP127274:2304991-2305401 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9152.66 Da        Isoelectric Point: 4.3228

>AT232224 WP_253357636.1 NZ_CP090959:3547736-3547984 [Simiduia sp. 21SJ11W-1]
VAYQILTEMAASISELKANPMKVVSSGEGMPIAVLNRNEPAFYCIPAKAYEAMINLIEDKELLEIVRARIDEESIKVRLD
DL

Download         Length: 249 bp

>AT232224 NZ_CP127274:2304765-2304998 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References