Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 3543897..3544405 Replicon chromosome
Accession NZ_CP090959
Organism Simiduia sp. 21SJ11W-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L1F30_RS15590 Protein ID WP_253357622.1
Coordinates 3544145..3544405 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag L1F30_RS15585 Protein ID WP_253357620.1
Coordinates 3543897..3544148 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F30_RS15565 (L1F30_15565) 3539466..3540251 + 786 WP_253357612.1 enoyl-CoA hydratase/isomerase family protein -
L1F30_RS15570 (L1F30_15570) 3540261..3542273 + 2013 WP_253357614.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
L1F30_RS15575 (L1F30_15575) 3542413..3543318 + 906 WP_253357616.1 hydroxymethylglutaryl-CoA lyase -
L1F30_RS15580 (L1F30_15580) 3543280..3543675 - 396 WP_253357618.1 MmcQ/YjbR family DNA-binding protein -
L1F30_RS15585 (L1F30_15585) 3543897..3544148 + 252 WP_253357620.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L1F30_RS15590 (L1F30_15590) 3544145..3544405 + 261 WP_253357622.1 Txe/YoeB family addiction module toxin Toxin
L1F30_RS15595 (L1F30_15595) 3544474..3544932 - 459 WP_253357630.1 hypothetical protein -
L1F30_RS15600 (L1F30_15600) 3545357..3545638 - 282 WP_253356743.1 hypothetical protein -
L1F30_RS15605 (L1F30_15605) 3545751..3546206 - 456 WP_253357632.1 lysozyme inhibitor LprI family protein -
L1F30_RS15610 (L1F30_15610) 3546661..3547119 - 459 WP_253356246.1 DUF2310 family Zn-ribbon-containing protein -
L1F30_RS15615 (L1F30_15615) 3547261..3547539 - 279 WP_253357634.1 hypothetical protein -
L1F30_RS15620 (L1F30_15620) 3547736..3547984 + 249 WP_253357636.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L1F30_RS15625 (L1F30_15625) 3547974..3548264 + 291 WP_253357638.1 type II toxin-antitoxin system RelE/ParE family toxin -
L1F30_RS15630 (L1F30_15630) 3548373..3548654 - 282 WP_253357640.1 hypothetical protein -
L1F30_RS15635 (L1F30_15635) 3548740..3549225 - 486 WP_253357642.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10268.67 Da        Isoelectric Point: 9.7859

>T232223 WP_253357622.1 NZ_CP090959:3544145-3544405 [Simiduia sp. 21SJ11W-1]
MKLTFSSRAWEEYLYWQKTDKAMVKRINALIKDTSRNPSEGIGKPEPLKHGLSGYWSRRINDEHRFVYKASDDGLLIAQL
RYHYEY

Download         Length: 261 bp

>T232223 NZ_CP127274:2242207-2242605 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 4.6362

>AT232223 WP_253357620.1 NZ_CP090959:3543897-3544148 [Simiduia sp. 21SJ11W-1]
MDAISYTAARANLAKTMERVCNDHSPVIITRKSEAPVVMVSLEDYQAMEETAYLLRSPANARHLLESIAELEAGKGSERE
LIE

Download         Length: 252 bp

>AT232223 NZ_CP127274:2241979-2242206 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References