Detailed information of TA system TA232218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 72608..73152
• Replicon: chromosome
• Accession: NZ_CP090954
• Organism: Xanthomonas arboricola pv. pruni strain Xcp1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L1B16_RS00265
• Protein ID: WP_228960823.1
• Coordinates: 72883..73152 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2N7V9L6
• Locus tag: L1B16_RS00260
• Protein ID: WP_016902922.1
• Coordinates: 72608..72865 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1B16_RS00245 (L1B16_10840)	67716..69224	-	1509	WP_043087410.1	ribonuclease H-like domain-containing protein	-
L1B16_RS00250 (L1B16_10845)	69221..71716	-	2496	WP_043087409.1	DEAD/DEAH box helicase	-
L1B16_RS00255 (L1B16_10850)	71890..72552	+	663	WP_039511099.1	hemolysin III family protein	-
L1B16_RS00260 (L1B16_10855)	72608..72865	+	258	WP_016902922.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L1B16_RS00265 (L1B16_10860)	72883..73152	+	270	WP_228960823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L1B16_RS00270 (L1B16_10865)	73271..73792	-	522	WP_051633992.1	hypothetical protein	-
L1B16_RS00275 (L1B16_10870)	73963..74316	-	354	WP_081327586.1	helix-turn-helix domain-containing protein	-
L1B16_RS00280 (L1B16_10875)	74349..74555	+	207	WP_223571151.1	hypothetical protein	-
L1B16_RS00285 (L1B16_10880)	74715..75806	-	1092	WP_039511112.1	ATP-grasp fold amidoligase family protein	-
L1B16_RS00290 (L1B16_10885)	76264..76977	+	714	WP_039511101.1	hypothetical protein	-
L1B16_RS00295 (L1B16_10890)	76988..77881	-	894	WP_104544175.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10221.75 Da
• Isoelectric Point: 10.1539

>T232218 WP_228960823.1 NZ_CP090954:72883-73152 [Xanthomonas arboricola pv. pruni]
VADLDAIADYIALEDAAAAAALVRRVFAHVEQLAEHPESGSRPQELKRSRYRQIVEPPCRVFYRVDGQRVVVVHVMRSER
LLRKNRLSR

Nucleotide

• Length: 270 bp

>T232218 NZ_CP127274:2185653-2186030 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9704.23 Da
• Isoelectric Point: 8.6056

>AT232218 WP_016902922.1 NZ_CP090954:72608-72865 [Xanthomonas arboricola pv. pruni]
MRTELVTTLKRQATELLADVERDKEPILITQHGLPSAYLVDVASYERMQQRMAILEGIARGEMAVAEGRSLSHEQAKQRL
ARWLK

Nucleotide

• Length: 258 bp

>AT232218 NZ_CP127274:2186072-2186521 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGTCATGA

Structures

Antitoxin

• AlphaFold DB: A0A2N7V9L6