Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 1621261..1621814 Replicon chromosome
Accession NZ_CP090953
Organism Sphingomonas sp. S2-65

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZ586_RS07605 Protein ID WP_235079227.1
Coordinates 1621261..1621584 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZ586_RS07610 Protein ID WP_235079229.1
Coordinates 1621581..1621814 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ586_RS07590 (LZ586_07625) 1616929..1619970 + 3042 WP_235079222.1 excinuclease ABC subunit UvrA -
LZ586_RS07595 (LZ586_07630) 1619974..1620696 - 723 WP_235079224.1 hypothetical protein -
LZ586_RS07600 (LZ586_07635) 1620693..1621103 - 411 WP_235079226.1 SocA family protein -
LZ586_RS07605 (LZ586_07640) 1621261..1621584 - 324 WP_235079227.1 DUF5615 family PIN-like protein Toxin
LZ586_RS07610 (LZ586_07645) 1621581..1621814 - 234 WP_235079229.1 DUF433 domain-containing protein Antitoxin
LZ586_RS07615 (LZ586_07650) 1622167..1623321 + 1155 WP_235079230.1 hypothetical protein -
LZ586_RS07620 (LZ586_07655) 1623611..1623826 + 216 WP_235079232.1 cold-shock protein -
LZ586_RS07625 (LZ586_07660) 1623898..1624101 + 204 WP_235079233.1 hypothetical protein -
LZ586_RS07630 (LZ586_07665) 1624098..1624244 + 147 WP_235079235.1 hypothetical protein -
LZ586_RS07635 (LZ586_07670) 1624592..1624744 + 153 WP_235079236.1 hypothetical protein -
LZ586_RS07640 (LZ586_07675) 1624887..1625387 + 501 WP_235079237.1 hypothetical protein -
LZ586_RS07645 (LZ586_07680) 1625405..1625872 + 468 WP_235079239.1 DUF3597 domain-containing protein -
LZ586_RS07650 (LZ586_07685) 1625876..1626343 + 468 WP_235079241.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-74)

Antitoxin

Protein of unknown function DUF433

(9-64)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12053.82 Da        Isoelectric Point: 4.6899

>T232216 WP_235079227.1 NZ_CP090953:c1621584-1621261 [Sphingomonas sp. S2-65]
MKFLVDAQLPPALCGWLRERGHEAEHVFEIGMVAASDADIAARAEADGAVLVSKDEDFVTLRLPDRFAFVWLRCGNATNR
ALLAWLEARWDQVQRLLAASERYIEVI

Download         Length: 324 bp

>T232216 NZ_CP127274:1958684-1958932 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8019.25 Da        Isoelectric Point: 4.3997

>AT232216 WP_235079229.1 NZ_CP090953:c1621814-1621581 [Sphingomonas sp. S2-65]
MTLAGFPRIAVDPLVCGGRPIVAGTRVRVTDVLEMLAGGASPGEIVGDFPYLSEEDVRAVLAYAARQADHPVVLAAE

Download         Length: 234 bp

>AT232216 NZ_CP127274:1958472-1958684 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References