Detailed information of TA system TA232214

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2014108..2014578
• Replicon: chromosome
• Accession: NZ_CP090941
• Organism: Staphylococcus epidermidis strain HAF242

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: LZT96_RS09660
• Protein ID: WP_001829569.1
• Coordinates: 2014390..2014578 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: LZT96_RS09655
• Protein ID: WP_074839211.1
• Coordinates: 2014108..2014365 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZT96_RS09620 (LZT96_09620)	2009372..2009914	-	543	WP_002476477.1	nitroreductase	-
LZT96_RS09625 (LZT96_09625)	2009995..2010711	-	717	WP_002498426.1	type I 3-dehydroquinate dehydratase	-
LZT96_RS09630 (LZT96_09630)	2010872..2011294	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
LZT96_RS09635 (LZT96_09635)	2011700..2012200	+	501	WP_002498425.1	GNAT family N-acetyltransferase	-
LZT96_RS09640 (LZT96_09640)	2012470..2013057	-	588	WP_002498424.1	histidine phosphatase family protein	-
LZT96_RS09645 (LZT96_09645)	2013270..2013506	+	237	WP_002457224.1	hypothetical protein	-
LZT96_RS09650 (LZT96_09650)	2013498..2013701	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
LZT96_RS09655 (LZT96_09655)	2014108..2014365	+	258	WP_074839211.1	hypothetical protein	Antitoxin
LZT96_RS09660 (LZT96_09660)	2014390..2014578	+	189	WP_001829569.1	hypothetical protein	Toxin
LZT96_RS09665 (LZT96_09665)	2014768..2015322	+	555	WP_002498423.1	lipoprotein N-acylation protein LnsA	-
LZT96_RS09670 (LZT96_09670)	2015382..2015615	-	234	WP_001829664.1	hypothetical protein	-
LZT96_RS09675 (LZT96_09675)	2015900..2016646	+	747	WP_002498422.1	poly-gamma-glutamate hydrolase family protein	-
LZT96_RS09680 (LZT96_09680)	2016744..2017028	+	285	WP_002474308.1	hypothetical protein	-
LZT96_RS09685 (LZT96_09685)	2017053..2017277	+	225	WP_002498421.1	hypothetical protein	-
LZT96_RS09690 (LZT96_09690)	2017912..2018112	-	201	WP_002493475.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-44)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T232214 WP_001829569.1 NZ_CP090941:2014390-2014578 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T232214 NZ_CP127274:1764978-1765382 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10044.08 Da
• Isoelectric Point: 4.5440

>AT232214 WP_074839211.1 NZ_CP090941:2014108-2014365 [Staphylococcus epidermidis]
MKLNKTNIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT232214 NZ_CP127274:1764769-1764972 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8