Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1992719..1993507 Replicon chromosome
Accession NZ_CP090941
Organism Staphylococcus epidermidis strain HAF242

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LZT96_RS09520 Protein ID WP_002484735.1
Coordinates 1993046..1993507 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LZT96_RS09515 Protein ID WP_002498323.1
Coordinates 1992719..1993033 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZT96_RS09460 (LZT96_09460) 1987904..1988680 - 777 WP_002468156.1 ATP-binding protein -
LZT96_RS09465 (LZT96_09465) 1988681..1989166 - 486 WP_002498316.1 siphovirus Gp157 family protein -
LZT96_RS09470 (LZT96_09470) 1989150..1989413 - 264 WP_002468154.1 hypothetical protein -
LZT96_RS09475 (LZT96_09475) 1989479..1989661 - 183 WP_002498317.1 hypothetical protein -
LZT96_RS09480 (LZT96_09480) 1989658..1989873 - 216 WP_002468180.1 hypothetical protein -
LZT96_RS09485 (LZT96_09485) 1989981..1990184 + 204 WP_002468183.1 hypothetical protein -
LZT96_RS09490 (LZT96_09490) 1990292..1990780 - 489 WP_002498318.1 ORF6C domain-containing protein -
LZT96_RS09495 (LZT96_09495) 1990839..1991219 + 381 WP_002498319.1 DUF2513 domain-containing protein -
LZT96_RS09500 (LZT96_09500) 1991211..1991387 - 177 WP_002498320.1 hypothetical protein -
LZT96_RS09505 (LZT96_09505) 1991398..1992315 - 918 WP_002498321.1 hypothetical protein -
LZT96_RS09510 (LZT96_09510) 1992330..1992566 - 237 WP_002498322.1 helix-turn-helix transcriptional regulator -
LZT96_RS09515 (LZT96_09515) 1992719..1993033 + 315 WP_002498323.1 helix-turn-helix transcriptional regulator Antitoxin
LZT96_RS09520 (LZT96_09520) 1993046..1993507 + 462 WP_002484735.1 ImmA/IrrE family metallo-endopeptidase Toxin
LZT96_RS09525 (LZT96_09525) 1993676..1993843 + 168 WP_002498324.1 hypothetical protein -
LZT96_RS09530 (LZT96_09530) 1993865..1995004 + 1140 WP_002498325.1 CapA family protein -
LZT96_RS09535 (LZT96_09535) 1995220..1996269 + 1050 WP_002498326.1 tyrosine-type recombinase/integrase -
LZT96_RS09540 (LZT96_09540) 1996337..1997734 - 1398 WP_002498327.1 Fe-S cluster assembly protein SufB -
LZT96_RS09545 (LZT96_09545) 1997929..1998393 - 465 WP_001831954.1 SUF system NifU family Fe-S cluster assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1955489..1997734 42245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(33-121)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17881.48 Da        Isoelectric Point: 5.0503

>T232213 WP_002484735.1 NZ_CP090941:1993046-1993507 [Staphylococcus epidermidis]
VGKYEDMLIEHDYIEVIECDNLPKRLSGLWLGDMILINRNLPITSKLETLAEELAHNELTYGNIVDQSSFNHRKFEGYAR
RLAYEKLVPLKDIVKAFLQGIHDLYELANFFEVTEGFVQQSIAHYKQKYGLTTRCGDYVIAFEPLRVFEYKEI

Download         Length: 462 bp

>T232213 NZ_CP127274:1686569-1686886 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12044.60 Da        Isoelectric Point: 5.7723

>AT232213 WP_002498323.1 NZ_CP090941:1992719-1993033 [Staphylococcus epidermidis]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAFLMGWIEDVEEQPQHRAAHL
DGDLTDEEWQEILDYAEYIRSKRK

Download         Length: 315 bp

>AT232213 NZ_CP127274:1686270-1686572 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References