Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 976007..976812 Replicon chromosome
Accession NZ_CP090941
Organism Staphylococcus epidermidis strain HAF242

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag LZT96_RS04665 Protein ID WP_002474496.1
Coordinates 976630..976812 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag LZT96_RS04660 Protein ID WP_002476983.1
Coordinates 976007..976606 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZT96_RS04635 (LZT96_04635) 971216..972673 + 1458 WP_002498152.1 ABC transporter substrate-binding protein/permease -
LZT96_RS04640 (LZT96_04640) 972666..973388 + 723 WP_002493983.1 amino acid ABC transporter ATP-binding protein -
LZT96_RS04645 (LZT96_04645) 973902..974039 + 138 WP_162158444.1 hypothetical protein -
LZT96_RS04650 (LZT96_04650) 974252..975382 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
LZT96_RS04655 (LZT96_04655) 975379..975849 + 471 WP_002493981.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LZT96_RS04660 (LZT96_04660) 976007..976606 + 600 WP_002476983.1 glucosamine-6-phosphate isomerase Antitoxin
LZT96_RS04665 (LZT96_04665) 976630..976812 + 183 WP_002474496.1 SAS053 family protein Toxin
LZT96_RS04670 (LZT96_04670) 976964..977368 + 405 WP_002474495.1 hypothetical protein -
LZT96_RS04675 (LZT96_04675) 977553..978938 + 1386 WP_002468497.1 class II fumarate hydratase -
LZT96_RS04680 (LZT96_04680) 979299..980123 - 825 WP_002498163.1 RluA family pseudouridine synthase -
LZT96_RS04685 (LZT96_04685) 980282..981415 + 1134 WP_002498162.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 973884..974039 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7084.66 Da        Isoelectric Point: 4.3016

>T232212 WP_002474496.1 NZ_CP090941:976630-976812 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQTHDNEVRSDFKNSK

Download         Length: 183 bp

>T232212 NZ_CP127274:1538389-1539210 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACTTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22679.60 Da        Isoelectric Point: 4.9942

>AT232212 WP_002476983.1 NZ_CP090941:976007-976606 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT232212 NZ_CP127274:1539203-1539439 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References