Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 820987..821516 Replicon chromosome
Accession NZ_CP090941
Organism Staphylococcus epidermidis strain HAF242

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag LZT96_RS03745 Protein ID WP_001829891.1
Coordinates 821154..821516 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag LZT96_RS03740 Protein ID WP_001829931.1
Coordinates 820987..821157 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZT96_RS03715 (LZT96_03715) 816811..817290 + 480 WP_001829909.1 PH domain-containing protein -
LZT96_RS03720 (LZT96_03720) 817283..818788 + 1506 WP_060556106.1 PH domain-containing protein -
LZT96_RS03725 (LZT96_03725) 818775..819284 + 510 WP_002494208.1 PH domain-containing protein -
LZT96_RS03730 (LZT96_03730) 819332..819685 + 354 WP_002498773.1 holo-ACP synthase -
LZT96_RS03735 (LZT96_03735) 819752..820900 + 1149 WP_002494207.1 alanine racemase -
LZT96_RS03740 (LZT96_03740) 820987..821157 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LZT96_RS03745 (LZT96_03745) 821154..821516 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LZT96_RS03750 (LZT96_03750) 821861..822862 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
LZT96_RS03755 (LZT96_03755) 822962..823288 + 327 WP_001829952.1 anti-sigma factor antagonist -
LZT96_RS03760 (LZT96_03760) 823290..823769 + 480 WP_002474646.1 anti-sigma B factor RsbW -
LZT96_RS03765 (LZT96_03765) 823744..824514 + 771 WP_002474636.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T232211 WP_001829891.1 NZ_CP090941:821154-821516 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T232211 NZ_CP127274:c1388977-1388684 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT232211 WP_001829931.1 NZ_CP090941:820987-821157 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT232211 NZ_CP127274:c1389243-1388974 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References