Detailed information of TA system TA232210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 809803..810312
• Replicon: chromosome
• Accession: NZ_CP090941
• Organism: Staphylococcus epidermidis strain HAF242

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: LZT96_RS03685
• Protein ID: WP_002474591.1
• Coordinates: 810109..810312 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: Q5HMD4
• Locus tag: LZT96_RS03680
• Protein ID: WP_001829893.1
• Coordinates: 809803..810096 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZT96_RS03655 (LZT96_03655)	804811..805599	+	789	WP_002498781.1	hydroxyethylthiazole kinase	-
LZT96_RS03660 (LZT96_03660)	805605..806243	+	639	WP_032603839.1	thiamine phosphate synthase	-
LZT96_RS03665 (LZT96_03665)	806332..807204	+	873	WP_002458703.1	membrane protein insertase YidC	-
LZT96_RS03670 (LZT96_03670)	807310..807963	-	654	WP_002498779.1	HD domain-containing protein	-
LZT96_RS03675 (LZT96_03675)	808145..809629	-	1485	WP_002498778.1	cardiolipin synthase	-
LZT96_RS03680 (LZT96_03680)	809803..810096	+	294	WP_001829893.1	copper-sensing transcriptional repressor CsoR	Antitoxin
LZT96_RS03685 (LZT96_03685)	810109..810312	+	204	WP_002474591.1	heavy-metal-associated domain-containing protein	Toxin
LZT96_RS03690 (LZT96_03690)	810455..810592	+	138	WP_002498777.1	Lmo0850 family protein	-
LZT96_RS03695 (LZT96_03695)	810691..811902	-	1212	WP_002498776.1	FtsW/RodA/SpoVE family cell cycle protein	-
LZT96_RS03700 (LZT96_03700)	812293..813366	+	1074	WP_001832735.1	D-alanine--D-alanine ligase	-
LZT96_RS03705 (LZT96_03705)	813378..814733	+	1356	WP_002498775.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (4-95)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7768.94 Da
• Isoelectric Point: 6.4587

>T232210 WP_002474591.1 NZ_CP090941:810109-810312 [Staphylococcus epidermidis]
MKKGLIHVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Nucleotide

• Length: 204 bp

>T232210 NZ_CP127274:1384534-1384965 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11070.65 Da
• Isoelectric Point: 5.5778

>AT232210 WP_001829893.1 NZ_CP090941:809803-810096 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT232210 NZ_CP127274:1384277-1384537 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0N1EPA7