Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/GNAT-DUF1778
Location 227719..228470 Replicon plasmid p1194_11_1
Accession NZ_CP090932
Organism Klebsiella pneumoniae strain ONE259

Toxin (Protein)


Gene name ataT Uniprot ID A0A8T3UHS1
Locus tag I7858_RS27010 Protein ID WP_004883482.1
Coordinates 227719..228201 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A8T3UKU4
Locus tag I7858_RS27015 Protein ID WP_004883484.1
Coordinates 228192..228470 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7858_RS26995 (I7858_26995) 223545..225278 + 1734 WP_025368656.1 PP2C family serine/threonine-protein phosphatase -
I7858_RS27000 (I7858_27000) 225306..226805 + 1500 WP_004196935.1 lipopolysaccharide kinase InaA family protein -
I7858_RS27005 (I7858_27005) 227184..227666 + 483 WP_004196929.1 hypothetical protein -
I7858_RS27010 (I7858_27010) 227719..228201 - 483 WP_004883482.1 GNAT family N-acetyltransferase Toxin
I7858_RS27015 (I7858_27015) 228192..228470 - 279 WP_004883484.1 DUF1778 domain-containing protein Antitoxin
I7858_RS27020 (I7858_27020) 228986..229954 - 969 WP_234552789.1 IS5 family transposase -
I7858_RS27025 (I7858_27025) 230759..231034 - 276 WP_001141269.1 formaldehyde-responsive transcriptional repressor FrmR -
I7858_RS28545 232735..233109 - 375 WP_227522231.1 DUF488 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / sul1 / qacE / aadA2 / dfrA15 / ARR-3 / dfrA8 / rmtG / sul2 / catA1 / formA - 1..266289 266289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(69-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17491.36 Da        Isoelectric Point: 9.4950

>T232208 WP_004883482.1 NZ_CP090932:c228201-227719 [Klebsiella pneumoniae]
MGMRPPEPLTPEHNIAEFCCQDQVINEWLKKKALRNHGTGISRVFVVCSENSKRVIAYYCLSSGSVHRNTVTGTYRRNAP
AAIPVIVLGRLAVDAAWAGKGIGAALLKDAIYRTEHIAVQVGVRALLVHALNDEVVAFYTKFGFETSAVNALTLLFPVKV

Download         Length: 483 bp

>T232208 NZ_CP127274:c1230970-1230659 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACACCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10720.23 Da        Isoelectric Point: 4.5423

>AT232208 WP_004883484.1 NZ_CP090932:c228470-228192 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEAACREAQDILLDQRLFLLDDKQFDTFIEELDAPVTPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT232208 NZ_CP127274:c1231290-1230970 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References