Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4724942..4725458 Replicon chromosome
Accession NZ_CP090931
Organism Klebsiella pneumoniae strain ONE259

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag I7858_RS23190 Protein ID WP_002886902.1
Coordinates 4724942..4725226 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I7858_RS23195 Protein ID WP_002886901.1
Coordinates 4725216..4725458 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7858_RS23165 (I7858_23165) 4720426..4720689 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
I7858_RS23170 (I7858_23170) 4720819..4720992 + 174 WP_002886906.1 hypothetical protein -
I7858_RS23175 (I7858_23175) 4720995..4721738 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I7858_RS23180 (I7858_23180) 4722095..4724233 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
I7858_RS23185 (I7858_23185) 4724474..4724938 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I7858_RS23190 (I7858_23190) 4724942..4725226 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I7858_RS23195 (I7858_23195) 4725216..4725458 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I7858_RS23200 (I7858_23200) 4725536..4727446 - 1911 WP_004152270.1 PRD domain-containing protein -
I7858_RS23205 (I7858_23205) 4727469..4728623 - 1155 WP_002886900.1 lactonase family protein -
I7858_RS23210 (I7858_23210) 4728689..4729429 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T232202 WP_002886902.1 NZ_CP090931:c4725226-4724942 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T232202 NZ_CP127274:c754992-754684 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT232202 WP_002886901.1 NZ_CP090931:c4725458-4725216 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT232202 NZ_CP127274:c755224-754979 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References