Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872116..872773 Replicon chromosome
Accession NZ_CP090931
Organism Klebsiella pneumoniae strain ONE259

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I7858_RS04400 Protein ID WP_002916310.1
Coordinates 872363..872773 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I7858_RS04395 Protein ID WP_002916312.1
Coordinates 872116..872382 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7858_RS04370 (I7858_04370) 867272..868705 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
I7858_RS04375 (I7858_04375) 868824..869552 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I7858_RS04380 (I7858_04380) 869602..869913 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
I7858_RS04385 (I7858_04385) 870077..870736 + 660 WP_002916317.1 hemolysin III family protein -
I7858_RS04390 (I7858_04390) 870887..871870 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I7858_RS04395 (I7858_04395) 872116..872382 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I7858_RS04400 (I7858_04400) 872363..872773 + 411 WP_002916310.1 protein YgfX Toxin
I7858_RS04405 (I7858_04405) 872780..873301 - 522 WP_002916308.1 flavodoxin FldB -
I7858_RS04410 (I7858_04410) 873402..874298 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I7858_RS04415 (I7858_04415) 874321..875034 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I7858_RS04420 (I7858_04420) 875040..876773 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T232190 WP_002916310.1 NZ_CP090931:872363-872773 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T232190 NZ_CP127274:363475-363777 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT232190 WP_002916312.1 NZ_CP090931:872116-872382 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT232190 NZ_CP127274:363825-364046 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References