Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4362170..4362813 Replicon chromosome
Accession NZ_CP090930
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.2430

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag L1L23_RS21505 Protein ID WP_000048134.1
Coordinates 4362397..4362813 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag L1L23_RS21500 Protein ID WP_001261294.1
Coordinates 4362170..4362400 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1L23_RS21490 (4359184) 4359184..4361322 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
L1L23_RS21495 (4361539) 4361539..4362003 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L1L23_RS21500 (4362170) 4362170..4362400 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L1L23_RS21505 (4362397) 4362397..4362813 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
L1L23_RS21510 (4362874) 4362874..4364787 - 1914 WP_001212127.1 BglG family transcription antiterminator -
L1L23_RS21515 (4364804) 4364804..4365544 - 741 WP_000779249.1 KDGP aldolase family protein -
L1L23_RS21520 (4365541) 4365541..4366659 - 1119 WP_001139179.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L1L23_RS21525 (4366643) 4366643..4367776 - 1134 WP_000459942.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T232184 WP_000048134.1 NZ_CP090930:4362397-4362813 [Salmonella enterica subsp. enterica serovar Agona]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T232184 NZ_CP127273:c3691047-3690619 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT232184 WP_001261294.1 NZ_CP090930:4362170-4362400 [Salmonella enterica subsp. enterica serovar Agona]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT232184 NZ_CP127273:c3691293-3691051 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References