Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4320787..4321337 Replicon chromosome
Accession NZ_CP090930
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.2430

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag L1L23_RS21285 Protein ID WP_001199743.1
Coordinates 4320787..4321095 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag L1L23_RS21290 Protein ID WP_000016244.1
Coordinates 4321098..4321337 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1L23_RS21265 (4315832) 4315832..4316287 + 456 WP_031602458.1 NUDIX domain-containing protein -
L1L23_RS21270 (4316578) 4316578..4318190 + 1613 Protein_4172 TraI domain-containing protein -
L1L23_RS21275 (4318180) 4318180..4319106 + 927 WP_000142420.1 site-specific integrase -
L1L23_RS21285 (4320787) 4320787..4321095 - 309 WP_001199743.1 CcdB family protein Toxin
L1L23_RS21290 (4321098) 4321098..4321337 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
L1L23_RS21295 (4321446) 4321446..4321694 - 249 WP_000254751.1 ribbon-helix-helix domain-containing protein -
L1L23_RS21300 (4321885) 4321885..4322316 - 432 Protein_4178 helix-turn-helix domain-containing protein -
L1L23_RS21315 (4323074) 4323074..4324093 + 1020 WP_000152567.1 NAD(P)-dependent alcohol dehydrogenase -
L1L23_RS21320 (4324121) 4324121..4324651 - 531 WP_000896759.1 gluconokinase -
L1L23_RS21325 (4324868) 4324868..4325899 + 1032 WP_000453362.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA7 - 4283674..4321694 38020
- inside IScluster/Tn - - 4319152..4322271 3119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T232183 WP_001199743.1 NZ_CP090930:c4321095-4320787 [Salmonella enterica subsp. enterica serovar Agona]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T232183 NZ_CP127273:3533351-3533695 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT232183 WP_000016244.1 NZ_CP090930:c4321337-4321098 [Salmonella enterica subsp. enterica serovar Agona]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT232183 NZ_CP127273:3533692-3534021 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCGGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References