Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 4304794..4306432 | Replicon | chromosome |
| Accession | NZ_CP090930 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R21.2430 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | B5F4A8 |
| Locus tag | L1L23_RS21215 | Protein ID | WP_001255026.1 |
| Coordinates | 4304794..4306122 (-) | Length | 443 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | B5F4A7 |
| Locus tag | L1L23_RS21220 | Protein ID | WP_001099274.1 |
| Coordinates | 4306127..4306432 (-) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1L23_RS21195 (4300332) | 4300332..4301315 | + | 984 | WP_000210270.1 | toll/interleukin-1 receptor domain-containing protein | - |
| L1L23_RS21200 (4301584) | 4301584..4302111 | - | 528 | WP_001043245.1 | hypothetical protein | - |
| L1L23_RS21205 (4302108) | 4302108..4303304 | - | 1197 | WP_000542997.1 | hypothetical protein | - |
| L1L23_RS21210 (4303493) | 4303493..4304482 | - | 990 | WP_077905772.1 | restriction endonuclease | - |
| L1L23_RS21215 (4304794) | 4304794..4306122 | - | 1329 | WP_001255026.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| L1L23_RS21220 (4306127) | 4306127..4306432 | - | 306 | WP_001099274.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L1L23_RS21225 (4307179) | 4307179..4307649 | + | 471 | WP_001222753.1 | hypothetical protein | - |
| L1L23_RS21235 (4309187) | 4309187..4309423 | + | 237 | WP_001748005.1 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
| L1L23_RS21240 (4309540) | 4309540..4310928 | - | 1389 | WP_000121182.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | fosA7 | - | 4283674..4321694 | 38020 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 443 a.a. Molecular weight: 50786.57 Da Isoelectric Point: 5.0474
>T232182 WP_001255026.1 NZ_CP090930:c4306122-4304794 [Salmonella enterica subsp. enterica serovar Agona]
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE
Download Length: 1329 bp
>T232182 NZ_CP127273:3166359-3166802 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11362.04 Da Isoelectric Point: 9.7765
>AT232182 WP_001099274.1 NZ_CP090930:c4306432-4306127 [Salmonella enterica subsp. enterica serovar Agona]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW
Download Length: 306 bp
>AT232182 NZ_CP127273:3166115-3166372 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L4S6F6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V5VUF2 |