232178

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3642220..3642840 Replicon chromosome
Accession NZ_CP090930
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.2430

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L1L23_RS17960 Protein ID WP_001280991.1
Coordinates 3642622..3642840 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L1L23_RS17955 Protein ID WP_000344807.1
Coordinates 3642220..3642594 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1L23_RS17945 (3637359) 3637359..3638552 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L1L23_RS17950 (3638575) 3638575..3641724 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L1L23_RS17955 (3642220) 3642220..3642594 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L1L23_RS17960 (3642622) 3642622..3642840 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L1L23_RS17965 (3643019) 3643019..3643570 + 552 WP_001278793.1 maltose O-acetyltransferase -
L1L23_RS17970 (3643688) 3643688..3644158 + 471 WP_000136183.1 YlaC family protein -
L1L23_RS17975 (3644214) 3644214..3644354 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L1L23_RS17980 (3644360) 3644360..3644620 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
L1L23_RS17985 (3644845) 3644845..3646395 + 1551 WP_000213148.1 EAL domain-containing protein -
L1L23_RS17995 (3646626) 3646626..3647015 + 390 WP_000961286.1 MGMT family protein -
L1L23_RS18000 (3647048) 3647048..3647617 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T232178 WP_001280991.1 NZ_CP090930:3642622-3642840 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T232178 NZ_CP127273:c3093505-3093149 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT232178 WP_000344807.1 NZ_CP090930:3642220-3642594 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT232178 NZ_CP127273:c3093719-3093489 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References