Detailed information of TA system TA232168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2566923..2567445
• Replicon: chromosome
• Accession: NZ_CP090930
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.2430

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: L1L23_RS12755
• Protein ID: WP_000221343.1
• Coordinates: 2566923..2567207 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: L1L23_RS12760
• Protein ID: WP_000885424.1
• Coordinates: 2567197..2567445 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1L23_RS12735 (2562998)	2562998..2564506	-	1509	WP_000199409.1	FAD-dependent oxidoreductase	-
L1L23_RS12740 (2564551)	2564551..2565039	+	489	WP_001293635.1	MarR family winged helix-turn-helix transcriptional regulator	-
L1L23_RS12745 (2565232)	2565232..2566311	+	1080	WP_000954697.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
L1L23_RS12750 (2566363)	2566363..2566752	-	390	WP_000194089.1	RidA family protein	-
L1L23_RS12755 (2566923)	2566923..2567207	-	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L1L23_RS12760 (2567197)	2567197..2567445	-	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L1L23_RS12765 (2567858)	2567858..2568211	-	354	WP_000418733.1	hypothetical protein	-
L1L23_RS12770 (2568214)	2568214..2568603	-	390	WP_001044696.1	hypothetical protein	-
L1L23_RS12775 (2568968)	2568968..2569075	+	108	Protein_2509	IS110 family transposase	-
L1L23_RS12780 (2569491)	2569491..2569823	+	333	WP_000253156.1	DUF1493 family protein	-
L1L23_RS12785 (2570098)	2570098..2570286	-	189	WP_001276021.1	DUF29 family protein	-
L1L23_RS12790 (2570699)	2570699..2571607	+	909	WP_001176641.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2565232..2574479	9247

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T232168 WP_000221343.1 NZ_CP090930:c2567207-2566923 [Salmonella enterica subsp. enterica serovar Agona]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T232168 NZ_CP127273:c2385492-2385175 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT232168 WP_000885424.1 NZ_CP090930:c2567445-2567197 [Salmonella enterica subsp. enterica serovar Agona]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT232168 NZ_CP127273:c2385704-2385489 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5