Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 209833..210593 Replicon chromosome
Accession NZ_CP090930
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.2430

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag L1L23_RS00980 Protein ID WP_000533909.1
Coordinates 210108..210593 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3J3UQX4
Locus tag L1L23_RS00975 Protein ID WP_000965888.1
Coordinates 209833..210120 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1L23_RS00955 (205163) 205163..206074 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
L1L23_RS00960 (206084) 206084..208153 + 2070 WP_001291732.1 glycine--tRNA ligase subunit beta -
L1L23_RS00965 (208615) 208615..209046 + 432 Protein_192 IS3 family transposase -
L1L23_RS00970 (209188) 209188..209655 + 468 WP_000702451.1 GNAT family N-acetyltransferase -
L1L23_RS00975 (209833) 209833..210120 + 288 WP_000965888.1 DUF1778 domain-containing protein Antitoxin
L1L23_RS00980 (210108) 210108..210593 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
L1L23_RS00985 (210965) 210965..211504 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
L1L23_RS00990 (211679) 211679..211891 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
L1L23_RS00995 (212179) 212179..212469 - 291 WP_000455790.1 HTH-type transcriptional regulator -
L1L23_RS01000 (212908) 212908..213618 + 711 WP_000190524.1 DUF3053 domain-containing protein -
L1L23_RS01005 (213668) 213668..214642 - 975 WP_000804680.1 glyoxylate/hydroxypyruvate reductase GhrB -
L1L23_RS01010 (214872) 214872..215534 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T232164 WP_000533909.1 NZ_CP090930:210108-210593 [Salmonella enterica subsp. enterica serovar Agona]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T232164 NZ_CP127273:c2217631-2217287 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10978.62 Da        Isoelectric Point: 4.6811

>AT232164 WP_000965888.1 NZ_CP090930:209833-210120 [Salmonella enterica subsp. enterica serovar Agona]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRIFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT232164 NZ_CP127273:c2217873-2217625 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3J3UQX4

References