Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 4307325..4308963 | Replicon | chromosome |
| Accession | NZ_CP090929 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R21.2429 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | B5F4A8 |
| Locus tag | L1L24_RS21230 | Protein ID | WP_001255026.1 |
| Coordinates | 4307325..4308653 (-) | Length | 443 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | B5F4A7 |
| Locus tag | L1L24_RS21235 | Protein ID | WP_001099274.1 |
| Coordinates | 4308658..4308963 (-) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1L24_RS21210 (4302863) | 4302863..4303846 | + | 984 | WP_000210270.1 | toll/interleukin-1 receptor domain-containing protein | - |
| L1L24_RS21215 (4304115) | 4304115..4304642 | - | 528 | WP_001043245.1 | hypothetical protein | - |
| L1L24_RS21220 (4304639) | 4304639..4305835 | - | 1197 | WP_000542997.1 | hypothetical protein | - |
| L1L24_RS21225 (4306024) | 4306024..4307013 | - | 990 | WP_077905772.1 | restriction endonuclease | - |
| L1L24_RS21230 (4307325) | 4307325..4308653 | - | 1329 | WP_001255026.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| L1L24_RS21235 (4308658) | 4308658..4308963 | - | 306 | WP_001099274.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L1L24_RS21240 (4309710) | 4309710..4310180 | + | 471 | WP_001222753.1 | hypothetical protein | - |
| L1L24_RS21250 (4311718) | 4311718..4311954 | + | 237 | WP_001748005.1 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
| L1L24_RS21255 (4312071) | 4312071..4313459 | - | 1389 | WP_000121182.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | fosA7 | - | 4286205..4324225 | 38020 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 443 a.a. Molecular weight: 50786.57 Da Isoelectric Point: 5.0474
>T232159 WP_001255026.1 NZ_CP090929:c4308653-4307325 [Salmonella enterica subsp. enterica serovar Agona]
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE
Download Length: 1329 bp
>T232159 NZ_CP127273:c2177955-2177626 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11362.04 Da Isoelectric Point: 9.7765
>AT232159 WP_001099274.1 NZ_CP090929:c4308963-4308658 [Salmonella enterica subsp. enterica serovar Agona]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW
Download Length: 306 bp
>AT232159 NZ_CP127273:c2178329-2177952 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L4S6F6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V5VUF2 |