Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3644751..3645371 Replicon chromosome
Accession NZ_CP090929
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.2429

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L1L24_RS17975 Protein ID WP_001280991.1
Coordinates 3645153..3645371 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L1L24_RS17970 Protein ID WP_000344807.1
Coordinates 3644751..3645125 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1L24_RS17960 (3639890) 3639890..3641083 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L1L24_RS17965 (3641106) 3641106..3644255 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L1L24_RS17970 (3644751) 3644751..3645125 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L1L24_RS17975 (3645153) 3645153..3645371 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L1L24_RS17980 (3645550) 3645550..3646101 + 552 WP_001278793.1 maltose O-acetyltransferase -
L1L24_RS17985 (3646219) 3646219..3646689 + 471 WP_000136183.1 YlaC family protein -
L1L24_RS17990 (3646745) 3646745..3646885 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L1L24_RS17995 (3646891) 3646891..3647151 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
L1L24_RS18000 (3647376) 3647376..3648926 + 1551 WP_000213148.1 EAL domain-containing protein -
L1L24_RS18010 (3649157) 3649157..3649546 + 390 WP_000961286.1 MGMT family protein -
L1L24_RS18015 (3649579) 3649579..3650148 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T232155 WP_001280991.1 NZ_CP090929:3645153-3645371 [Salmonella enterica subsp. enterica serovar Agona]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T232155 NZ_CP127273:1685878-1686195 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT232155 WP_000344807.1 NZ_CP090929:3644751-3645125 [Salmonella enterica subsp. enterica serovar Agona]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT232155 NZ_CP127273:1685579-1685881 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References