Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1720602..1722225 Replicon chromosome
Accession NZ_CP090929
Organism Salmonella enterica subsp. enterica serovar Agona strain R21.2429

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag L1L24_RS08320 Protein ID WP_000088046.1
Coordinates 1720602..1721927 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag L1L24_RS08325 Protein ID WP_024136327.1
Coordinates 1721932..1722225 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1L24_RS08280 (1715623) 1715623..1715979 + 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -
L1L24_RS08285 (1716321) 1716321..1716524 - 204 WP_001194555.1 hypothetical protein -
L1L24_RS08290 (1716586) 1716586..1717443 - 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
L1L24_RS08295 (1717459) 1717459..1717767 - 309 WP_001224687.1 hypothetical protein -
L1L24_RS08300 (1718316) 1718316..1718741 - 426 WP_001043843.1 hypothetical protein -
L1L24_RS08305 (1718995) 1718995..1719810 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
L1L24_RS08310 (1719823) 1719823..1720233 - 411 WP_000985911.1 hypothetical protein -
L1L24_RS08315 (1720335) 1720335..1720541 - 207 WP_000134171.1 hypothetical protein -
L1L24_RS08320 (1720602) 1720602..1721927 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
L1L24_RS08325 (1721932) 1721932..1722225 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
L1L24_RS08330 (1722829) 1722829..1723221 - 393 WP_000341066.1 hypothetical protein -
L1L24_RS08335 (1723594) 1723594..1723929 + 336 WP_065311125.1 hypothetical protein -
L1L24_RS08340 (1723968) 1723968..1724765 - 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
L1L24_RS08345 (1724765) 1724765..1725937 - 1173 WP_000952349.1 IS21-like element IS21 family transposase -
L1L24_RS08350 (1725978) 1725978..1726475 + 498 WP_133322300.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element floR / aph(3')-Ia / dfrA14 rcsB 1673060..1786895 113835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T232144 WP_000088046.1 NZ_CP090929:c1721927-1720602 [Salmonella enterica subsp. enterica serovar Agona]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T232144 NZ_CP127273:c755080-754643 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT232144 WP_024136327.1 NZ_CP090929:c1722225-1721932 [Salmonella enterica subsp. enterica serovar Agona]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT232144 NZ_CP127273:c754533-754288 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References