Detailed information of TA system TA232140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1962038..1962508
• Replicon: chromosome
• Accession: NZ_CP090922
• Organism: Staphylococcus epidermidis strain 45A6

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: KB230_RS09305
• Protein ID: WP_001829569.1
• Coordinates: 1962320..1962508 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: KB230_RS09300
• Protein ID: WP_002438963.1
• Coordinates: 1962038..1962295 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KB230_RS09265 (KB230_09265)	1957403..1958119	-	717	WP_002468876.1	type I 3-dehydroquinate dehydratase	-
KB230_RS09270 (KB230_09270)	1958280..1958702	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
KB230_RS09275 (KB230_09275)	1959052..1959239	-	188	Protein_1803	hypothetical protein	-
KB230_RS09280 (KB230_09280)	1959626..1960126	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
KB230_RS09285 (KB230_09285)	1960397..1960984	-	588	WP_002468863.1	histidine phosphatase family protein	-
KB230_RS09290 (KB230_09290)	1961198..1961434	+	237	WP_002500396.1	hypothetical protein	-
KB230_RS09295 (KB230_09295)	1961426..1961629	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
KB230_RS09300 (KB230_09300)	1962038..1962295	+	258	WP_002438963.1	hypothetical protein	Antitoxin
KB230_RS09305 (KB230_09305)	1962320..1962508	+	189	WP_001829569.1	hypothetical protein	Toxin
KB230_RS09310 (KB230_09310)	1962698..1963252	+	555	WP_001829566.1	lipoprotein N-acylation protein LnsA	-
KB230_RS09315 (KB230_09315)	1963312..1963545	-	234	WP_234967010.1	hypothetical protein	-
KB230_RS09320 (KB230_09320)	1963829..1964575	+	747	WP_002495246.1	poly-gamma-glutamate hydrolase family protein	-
KB230_RS09325 (KB230_09325)	1964674..1964958	+	285	WP_001829635.1	hypothetical protein	-
KB230_RS09330 (KB230_09330)	1964982..1965206	+	225	WP_001829613.1	hypothetical protein	-
KB230_RS09335 (KB230_09335)	1965827..1966027	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T232140 WP_001829569.1 NZ_CP090922:1962320-1962508 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T232140 NZ_CP127273:715972-716367 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT232140 WP_002438963.1 NZ_CP090922:1962038-1962295 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT232140 NZ_CP127273:715718-715972 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3