232139

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 964159..964961 Replicon chromosome
Accession NZ_CP090922
Organism Staphylococcus epidermidis strain 45A6

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KB230_RS04590 Protein ID WP_002468490.1
Coordinates 964782..964961 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KB230_RS04585 Protein ID WP_002456349.1
Coordinates 964159..964758 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB230_RS04565 (KB230_04565) 959371..960828 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KB230_RS04570 (KB230_04570) 960821..961543 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KB230_RS11685 962058..962189 + 132 WP_255264851.1 hypothetical protein -
KB230_RS04575 (KB230_04575) 962404..963534 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KB230_RS04580 (KB230_04580) 963531..964001 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KB230_RS04585 (KB230_04585) 964159..964758 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KB230_RS04590 (KB230_04590) 964782..964961 + 180 WP_002468490.1 SAS053 family protein Toxin
KB230_RS04595 (KB230_04595) 965117..965521 + 405 WP_001829818.1 hypothetical protein -
KB230_RS04600 (KB230_04600) 965706..967091 + 1386 WP_001829862.1 class II fumarate hydratase -
KB230_RS04605 (KB230_04605) 967452..968276 - 825 WP_001829804.1 RluA family pseudouridine synthase -
KB230_RS04610 (KB230_04610) 968435..969568 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T232139 WP_002468490.1 NZ_CP090922:964782-964961 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T232139 NZ_CP127273:710314-710715 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT232139 WP_002456349.1 NZ_CP090922:964159-964758 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT232139 NZ_CP127273:710090-710317 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References