Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 813218..813747 Replicon chromosome
Accession NZ_CP090922
Organism Staphylococcus epidermidis strain 45A6

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KB230_RS03745 Protein ID WP_001829891.1
Coordinates 813385..813747 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KB230_RS03740 Protein ID WP_001829931.1
Coordinates 813218..813388 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB230_RS03715 (KB230_03715) 809042..809521 + 480 WP_002457111.1 PH domain-containing protein -
KB230_RS03720 (KB230_03720) 809514..811019 + 1506 WP_002457110.1 PH domain-containing protein -
KB230_RS03725 (KB230_03725) 811006..811515 + 510 WP_002457109.1 PH domain-containing protein -
KB230_RS03730 (KB230_03730) 811563..811916 + 354 WP_002457108.1 holo-ACP synthase -
KB230_RS03735 (KB230_03735) 811983..813131 + 1149 WP_002457107.1 alanine racemase -
KB230_RS03740 (KB230_03740) 813218..813388 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KB230_RS03745 (KB230_03745) 813385..813747 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KB230_RS03750 (KB230_03750) 814092..815093 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KB230_RS03755 (KB230_03755) 815193..815519 + 327 WP_001829952.1 anti-sigma factor antagonist -
KB230_RS03760 (KB230_03760) 815521..816000 + 480 WP_001829903.1 anti-sigma B factor RsbW -
KB230_RS03765 (KB230_03765) 815975..816745 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T232138 WP_001829891.1 NZ_CP090922:813385-813747 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T232138 NZ_CP127273:702794-703195 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT232138 WP_001829931.1 NZ_CP090922:813218-813388 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT232138 NZ_CP127273:702552-702797 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References