232137

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 802033..802542 Replicon chromosome
Accession NZ_CP090922
Organism Staphylococcus epidermidis strain 45A6

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KB230_RS03685 Protein ID WP_001829980.1
Coordinates 802333..802542 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KB230_RS03680 Protein ID WP_001829893.1
Coordinates 802033..802326 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB230_RS03655 (KB230_03655) 797041..797829 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KB230_RS03660 (KB230_03660) 797835..798473 + 639 WP_002505076.1 thiamine phosphate synthase -
KB230_RS03665 (KB230_03665) 798562..799434 + 873 WP_002458703.1 membrane protein insertase YidC -
KB230_RS03670 (KB230_03670) 799540..800193 - 654 WP_001829983.1 HD domain-containing protein -
KB230_RS03675 (KB230_03675) 800375..801859 - 1485 WP_002457116.1 cardiolipin synthase -
KB230_RS03680 (KB230_03680) 802033..802326 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KB230_RS03685 (KB230_03685) 802333..802542 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KB230_RS03690 (KB230_03690) 802685..802822 + 138 WP_001829949.1 Lmo0850 family protein -
KB230_RS03695 (KB230_03695) 802921..804132 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
KB230_RS03700 (KB230_03700) 804523..805596 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
KB230_RS03705 (KB230_03705) 805608..806963 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T232137 WP_001829980.1 NZ_CP090922:802333-802542 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T232137 NZ_CP127273:c696875-696462 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT232137 WP_001829893.1 NZ_CP090922:802033-802326 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT232137 NZ_CP127273:c697108-696872 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References