232133

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2006237..2006707 Replicon chromosome
Accession NZ_CP090915
Organism Staphylococcus epidermidis strain 45A5

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KB229_RS09705 Protein ID WP_001829569.1
Coordinates 2006519..2006707 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KB229_RS09700 Protein ID WP_002438963.1
Coordinates 2006237..2006494 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB229_RS09660 (KB229_09660) 2001601..2002317 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KB229_RS09665 (KB229_09665) 2002478..2002900 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KB229_RS09670 (KB229_09670) 2003084..2003221 - 138 WP_162161215.1 hypothetical protein -
KB229_RS09675 (KB229_09675) 2003251..2003438 - 188 Protein_1880 hypothetical protein -
KB229_RS09680 (KB229_09680) 2003825..2004325 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KB229_RS09685 (KB229_09685) 2004596..2005183 - 588 WP_001829615.1 histidine phosphatase family protein -
KB229_RS09690 (KB229_09690) 2005397..2005633 + 237 WP_002457224.1 hypothetical protein -
KB229_RS09695 (KB229_09695) 2005625..2005828 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KB229_RS09700 (KB229_09700) 2006237..2006494 + 258 WP_002438963.1 hypothetical protein Antitoxin
KB229_RS09705 (KB229_09705) 2006519..2006707 + 189 WP_001829569.1 hypothetical protein Toxin
KB229_RS09710 (KB229_09710) 2006897..2007451 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KB229_RS09715 (KB229_09715) 2007511..2007744 - 234 WP_234965934.1 hypothetical protein -
KB229_RS09720 (KB229_09720) 2008028..2008774 + 747 WP_234965936.1 poly-gamma-glutamate hydrolase family protein -
KB229_RS09725 (KB229_09725) 2008873..2009157 + 285 WP_001829635.1 hypothetical protein -
KB229_RS09730 (KB229_09730) 2009181..2009405 + 225 WP_001829613.1 hypothetical protein -
KB229_RS09735 (KB229_09735) 2010026..2010226 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1941993..2024916 82923
- flank IS/Tn - - 2003084..2003239 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T232133 WP_001829569.1 NZ_CP090915:2006519-2006707 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T232133 NZ_CP127273:c444123-443530 [Mycobacterium tuberculosis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT232133 WP_002438963.1 NZ_CP090915:2006237-2006494 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT232133 NZ_CP127273:c444541-444152 [Mycobacterium tuberculosis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References