Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1001136..1001942 Replicon chromosome
Accession NZ_CP090915
Organism Staphylococcus epidermidis strain 45A5

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag KB229_RS04890 Protein ID WP_234966404.1
Coordinates 1001136..1001600 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag KB229_RS04895 Protein ID WP_002439260.1
Coordinates 1001613..1001942 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB229_RS04870 (KB229_04870) 997066..997536 - 471 Protein_921 site-specific integrase -
KB229_RS04875 (KB229_04875) 997642..998040 - 399 Protein_922 phage integrase SAM-like domain-containing protein -
KB229_RS04880 (KB229_04880) 998095..999120 - 1026 WP_234966402.1 restriction endonuclease subunit S -
KB229_RS04885 (KB229_04885) 999107..1000981 - 1875 WP_234966574.1 N-6 DNA methylase -
KB229_RS04890 (KB229_04890) 1001136..1001600 - 465 WP_234966404.1 ImmA/IrrE family metallo-endopeptidase Toxin
KB229_RS04895 (KB229_04895) 1001613..1001942 - 330 WP_002439260.1 helix-turn-helix transcriptional regulator Antitoxin
KB229_RS04900 (KB229_04900) 1002136..1002375 + 240 WP_234966406.1 helix-turn-helix transcriptional regulator -
KB229_RS04905 (KB229_04905) 1002389..1002622 + 234 WP_234966408.1 DUF2829 domain-containing protein -
KB229_RS04910 (KB229_04910) 1002644..1002808 + 165 WP_176746971.1 hypothetical protein -
KB229_RS04915 (KB229_04915) 1002812..1003024 + 213 WP_234966410.1 DUF771 domain-containing protein -
KB229_RS04920 (KB229_04920) 1003037..1003213 + 177 WP_234966412.1 hypothetical protein -
KB229_RS04925 (KB229_04925) 1003277..1003513 + 237 WP_039973868.1 hypothetical protein -
KB229_RS04930 (KB229_04930) 1003506..1003991 + 486 WP_234966414.1 siphovirus Gp157 family protein -
KB229_RS04935 (KB229_04935) 1003992..1004693 + 702 WP_234966416.1 AAA family ATPase -
KB229_RS04940 (KB229_04940) 1004680..1006089 + 1410 WP_234966418.1 DEAD/DEAH box helicase -
KB229_RS04945 (KB229_04945) 1006105..1006650 + 546 WP_234966420.1 DUF669 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 992624..1044143 51519


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(33-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18297.86 Da        Isoelectric Point: 5.2817

>T232132 WP_234966404.1 NZ_CP090915:c1001600-1001136 [Staphylococcus epidermidis]
VGKYEDMLIEHDYIEVIECDKLPNDLYGLWLGDMILINRNLPITSKLETLAEELAHNELTYGNIANQNNFNHRKFEGYAR
KLAYEKLVPLKDIVKAFLQDIHNLYELANFFEVTESFVIQSIEHYKQKHGYSTRYGKYVIQFEPLRVFEYKNIE

Download         Length: 465 bp

>T232132 NZ_CP127273:363352-363777 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12735.32 Da        Isoelectric Point: 5.7917

>AT232132 WP_002439260.1 NZ_CP090915:c1001942-1001613 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT232132 NZ_CP127273:363134-363355 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References