Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 811118..811647 Replicon chromosome
Accession NZ_CP090915
Organism Staphylococcus epidermidis strain 45A5

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KB229_RS03785 Protein ID WP_001829891.1
Coordinates 811285..811647 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KB229_RS03780 Protein ID WP_001829931.1
Coordinates 811118..811288 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB229_RS03755 (KB229_03755) 806942..807421 + 480 WP_002457111.1 PH domain-containing protein -
KB229_RS03760 (KB229_03760) 807414..808919 + 1506 WP_002457110.1 PH domain-containing protein -
KB229_RS03765 (KB229_03765) 808906..809415 + 510 WP_002457109.1 PH domain-containing protein -
KB229_RS03770 (KB229_03770) 809463..809816 + 354 WP_002457108.1 holo-ACP synthase -
KB229_RS03775 (KB229_03775) 809883..811031 + 1149 WP_145398696.1 alanine racemase -
KB229_RS03780 (KB229_03780) 811118..811288 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KB229_RS03785 (KB229_03785) 811285..811647 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KB229_RS03790 (KB229_03790) 811992..812993 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KB229_RS03795 (KB229_03795) 813093..813419 + 327 WP_001829952.1 anti-sigma factor antagonist -
KB229_RS03800 (KB229_03800) 813421..813900 + 480 WP_001829903.1 anti-sigma B factor RsbW -
KB229_RS03805 (KB229_03805) 813875..814645 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T232130 WP_001829891.1 NZ_CP090915:811285-811647 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T232130 NZ_CP127273:362784-363086 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT232130 WP_001829931.1 NZ_CP090915:811118-811288 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT232130 NZ_CP127273:362560-362787 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References