232129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 799933..800442 Replicon chromosome
Accession NZ_CP090915
Organism Staphylococcus epidermidis strain 45A5

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KB229_RS03725 Protein ID WP_001829980.1
Coordinates 800233..800442 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KB229_RS03720 Protein ID WP_001829893.1
Coordinates 799933..800226 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB229_RS03695 (KB229_03695) 794941..795729 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KB229_RS03700 (KB229_03700) 795735..796373 + 639 WP_002505076.1 thiamine phosphate synthase -
KB229_RS03705 (KB229_03705) 796462..797334 + 873 WP_002458703.1 membrane protein insertase YidC -
KB229_RS03710 (KB229_03710) 797440..798093 - 654 WP_001829983.1 HD domain-containing protein -
KB229_RS03715 (KB229_03715) 798275..799759 - 1485 WP_234966336.1 cardiolipin synthase -
KB229_RS03720 (KB229_03720) 799933..800226 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KB229_RS03725 (KB229_03725) 800233..800442 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KB229_RS03730 (KB229_03730) 800585..800722 + 138 WP_001829949.1 Lmo0850 family protein -
KB229_RS03735 (KB229_03735) 800821..802032 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
KB229_RS03740 (KB229_03740) 802423..803496 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
KB229_RS03745 (KB229_03745) 803508..804863 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T232129 WP_001829980.1 NZ_CP090915:800233-800442 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T232129 NZ_CP127273:71821-72222 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT232129 WP_001829893.1 NZ_CP090915:799933-800226 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT232129 NZ_CP127273:71589-71828 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References