232128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1923306..1923776 Replicon chromosome
Accession NZ_CP090912
Organism Staphylococcus epidermidis strain 44

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KB228_RS09065 Protein ID WP_001829569.1
Coordinates 1923588..1923776 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KB228_RS09060 Protein ID WP_002438963.1
Coordinates 1923306..1923563 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB228_RS09020 (KB228_09020) 1918669..1919385 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KB228_RS09025 (KB228_09025) 1919546..1919968 + 423 WP_234963875.1 organic hydroperoxide resistance protein -
KB228_RS09030 (KB228_09030) 1920152..1920289 - 138 WP_162161215.1 hypothetical protein -
KB228_RS09035 (KB228_09035) 1920319..1920506 - 188 Protein_1747 hypothetical protein -
KB228_RS09040 (KB228_09040) 1920894..1921394 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KB228_RS09045 (KB228_09045) 1921665..1922252 - 588 WP_001829615.1 histidine phosphatase family protein -
KB228_RS09050 (KB228_09050) 1922466..1922702 + 237 WP_002457224.1 hypothetical protein -
KB228_RS09055 (KB228_09055) 1922694..1922897 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KB228_RS09060 (KB228_09060) 1923306..1923563 + 258 WP_002438963.1 hypothetical protein Antitoxin
KB228_RS09065 (KB228_09065) 1923588..1923776 + 189 WP_001829569.1 hypothetical protein Toxin
KB228_RS09070 (KB228_09070) 1923966..1924520 + 555 WP_002495245.1 lipoprotein N-acylation protein LnsA -
KB228_RS09075 (KB228_09075) 1924580..1924813 - 234 WP_001829664.1 hypothetical protein -
KB228_RS09080 (KB228_09080) 1925097..1925843 + 747 WP_002495246.1 poly-gamma-glutamate hydrolase family protein -
KB228_RS09085 (KB228_09085) 1925942..1926226 + 285 WP_001829635.1 hypothetical protein -
KB228_RS09090 (KB228_09090) 1926250..1926474 + 225 WP_001829613.1 hypothetical protein -
KB228_RS09095 (KB228_09095) 1927095..1927295 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1914277..1927295 13018
- flank IS/Tn - - 1920152..1920307 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(10-63)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T232128 WP_001829569.1 NZ_CP090912:1923588-1923776 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T232128 NZ_CP127260:29100-29360 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT232128 WP_002438963.1 NZ_CP090912:1923306-1923563 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT232128 NZ_CP127260:29350-29601 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References