Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 779354..779883 Replicon chromosome
Accession NZ_CP090912
Organism Staphylococcus epidermidis strain 44

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KB228_RS03580 Protein ID WP_001829891.1
Coordinates 779521..779883 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KB228_RS03575 Protein ID WP_001829931.1
Coordinates 779354..779524 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB228_RS03550 (KB228_03550) 775178..775657 + 480 WP_002457111.1 PH domain-containing protein -
KB228_RS03555 (KB228_03555) 775650..777155 + 1506 WP_002457110.1 PH domain-containing protein -
KB228_RS03560 (KB228_03560) 777142..777651 + 510 WP_002457109.1 PH domain-containing protein -
KB228_RS03565 (KB228_03565) 777699..778052 + 354 WP_002457108.1 holo-ACP synthase -
KB228_RS03570 (KB228_03570) 778119..779267 + 1149 WP_002457107.1 alanine racemase -
KB228_RS03575 (KB228_03575) 779354..779524 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KB228_RS03580 (KB228_03580) 779521..779883 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KB228_RS03585 (KB228_03585) 780228..781229 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KB228_RS03590 (KB228_03590) 781329..781655 + 327 WP_001829952.1 anti-sigma factor antagonist -
KB228_RS03595 (KB228_03595) 781657..782136 + 480 WP_001829903.1 anti-sigma B factor RsbW -
KB228_RS03600 (KB228_03600) 782111..782881 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T232126 WP_001829891.1 NZ_CP090912:779521-779883 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T232126 NZ_CP127256:113751-113900 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGCGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT232126 WP_001829931.1 NZ_CP090912:779354-779524 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT232126 NZ_CP127256:c113703-113647 [Escherichia coli]
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References