Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 768170..768679 Replicon chromosome
Accession NZ_CP090912
Organism Staphylococcus epidermidis strain 44

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KB228_RS03520 Protein ID WP_001829980.1
Coordinates 768470..768679 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KB228_RS03515 Protein ID WP_001829893.1
Coordinates 768170..768463 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB228_RS03490 (KB228_03490) 763178..763966 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KB228_RS03495 (KB228_03495) 763972..764610 + 639 WP_002505076.1 thiamine phosphate synthase -
KB228_RS03500 (KB228_03500) 764699..765571 + 873 WP_002458703.1 membrane protein insertase YidC -
KB228_RS03505 (KB228_03505) 765677..766330 - 654 WP_001829983.1 HD domain-containing protein -
KB228_RS03510 (KB228_03510) 766512..767996 - 1485 WP_002457116.1 cardiolipin synthase -
KB228_RS03515 (KB228_03515) 768170..768463 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KB228_RS03520 (KB228_03520) 768470..768679 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KB228_RS03525 (KB228_03525) 768822..768959 + 138 WP_001829949.1 Lmo0850 family protein -
KB228_RS03530 (KB228_03530) 769058..770269 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
KB228_RS03535 (KB228_03535) 770660..771733 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
KB228_RS03540 (KB228_03540) 771745..773100 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T232125 WP_001829980.1 NZ_CP090912:768470-768679 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T232125 NZ_CP127256:c103136-102738 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCCTTGATGTTCTGGATTACGACGCCGCTGCAGCCACACATACC
GGCCAGATAAGGGCAGAACTTGCCCGTCAGGGACGTCCTGTCGGACCATTTGATCAAATGATCGCAGGCCATGCCCGCAG
CCGGGGGCTGATAGTTGTGACTAACAACATCCGGGAATTTGAACGTATGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT232125 WP_001829893.1 NZ_CP090912:768170-768463 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT232125 NZ_CP127256:c103363-103136 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGTATCATTACGCCAGCCGGAGAATCATGGGATGAATGGTTCGACGGAA
ACAGCGTCAGCGCCGATTTTATGGATAACCGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References