Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 102617..103143 Replicon plasmid pM1
Accession NZ_CP090910
Organism Enterobacter hormaechei strain M1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag L1E13_RS22690 Protein ID WP_000323025.1
Coordinates 102856..103143 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag L1E13_RS22685 Protein ID WP_004196370.1
Coordinates 102617..102856 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1E13_RS22660 (L1E13_22660) 98206..98862 - 657 WP_001516695.1 quinolone resistance pentapeptide repeat protein QnrS1 -
L1E13_RS22665 (L1E13_22665) 99257..100410 + 1154 Protein_107 IS3 family transposase -
L1E13_RS22670 (L1E13_22670) 100459..101157 - 699 Protein_108 class A beta-lactamase -
L1E13_RS22680 (L1E13_22680) 102494..102592 - 99 Protein_110 protein YdfV -
L1E13_RS22685 (L1E13_22685) 102617..102856 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
L1E13_RS22690 (L1E13_22690) 102856..103143 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
L1E13_RS22695 (L1E13_22695) 103210..104244 - 1035 Protein_113 IS481 family transposase -
L1E13_RS22700 (L1E13_22700) 104316..104474 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
L1E13_RS22705 (L1E13_22705) 105350..105664 + 315 WP_044157807.1 hypothetical protein -
L1E13_RS22710 (L1E13_22710) 105725..106186 + 462 WP_013087181.1 hypothetical protein -
L1E13_RS22715 (L1E13_22715) 106274..106474 + 201 WP_013087182.1 hypothetical protein -
L1E13_RS22720 (L1E13_22720) 106515..107306 + 792 WP_013087183.1 N-6 DNA methylase -
L1E13_RS22725 (L1E13_22725) 107348..107683 + 336 WP_013087184.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid catA2 / tet(D) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / qnrS1 / blaLAP-2 - 1..148434 148434
- inside IScluster/Tn catA2 / tet(D) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / qnrS1 / blaLAP-2 - 71412..104244 32832


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T232124 WP_000323025.1 NZ_CP090910:102856-103143 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T232124 NZ_CP127256:5284-5559 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT232124 WP_004196370.1 NZ_CP090910:102617-102856 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT232124 NZ_CP127256:5006-5284 [Escherichia coli]
ATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGACCAGAT
AGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGGAGCGTA
ATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGATTATCGACCATCAGGCTGTACAGGCCTGGGCGGAC
AGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References