Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 28978..29717 Replicon plasmid pM1
Accession NZ_CP090910
Organism Enterobacter hormaechei strain M1

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag L1E13_RS22275 Protein ID WP_013087269.1
Coordinates 28978..29463 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag L1E13_RS22280 Protein ID WP_007869691.1
Coordinates 29451..29717 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1E13_RS22250 (L1E13_22250) 24099..24440 - 342 WP_001151575.1 hypothetical protein -
L1E13_RS22255 (L1E13_22255) 24565..25533 + 969 WP_072199635.1 IS5 family transposase -
L1E13_RS22260 (L1E13_22260) 25760..26880 + 1121 WP_087451024.1 IS3-like element ISSen4 family transposase -
L1E13_RS22270 (L1E13_22270) 27793..28611 + 819 WP_013087268.1 abortive infection family protein -
L1E13_RS22275 (L1E13_22275) 28978..29463 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
L1E13_RS22280 (L1E13_22280) 29451..29717 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
L1E13_RS22285 (L1E13_22285) 30370..31383 + 1014 WP_013087098.1 plasmid replication initiator RepA -
L1E13_RS22290 (L1E13_22290) 32334..33140 + 807 WP_013087100.1 DUF4225 domain-containing protein -
L1E13_RS22295 (L1E13_22295) 33115..33444 - 330 WP_013087101.1 hypothetical protein -
L1E13_RS22300 (L1E13_22300) 33527..33865 - 339 WP_013087102.1 hypothetical protein -
L1E13_RS22305 (L1E13_22305) 33880..34650 - 771 WP_013087103.1 TraX family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid catA2 / tet(D) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / qnrS1 / blaLAP-2 - 1..148434 148434


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T232122 WP_013087269.1 NZ_CP090910:c29463-28978 [Enterobacter hormaechei]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T232122 NZ_CP127255:c4796135-4795728 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGACGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT232122 WP_007869691.1 NZ_CP090910:c29717-29451 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT232122 NZ_CP127255:c4796382-4796116 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References