Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3837466..3838086 Replicon chromosome
Accession NZ_CP090909
Organism Enterobacter hormaechei strain M1

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag L1E13_RS18195 Protein ID WP_015571250.1
Coordinates 3837466..3837684 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag L1E13_RS18200 Protein ID WP_006809850.1
Coordinates 3837712..3838086 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1E13_RS18165 (L1E13_18165) 3833478..3833738 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
L1E13_RS18170 (L1E13_18170) 3833741..3833881 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
L1E13_RS18175 (L1E13_18175) 3833878..3834588 - 711 WP_022650493.1 GNAT family protein -
L1E13_RS18180 (L1E13_18180) 3834690..3836150 + 1461 WP_032608667.1 PLP-dependent aminotransferase family protein -
L1E13_RS18185 (L1E13_18185) 3836122..3836589 - 468 WP_022650495.1 YlaC family protein -
L1E13_RS18190 (L1E13_18190) 3836706..3837257 - 552 WP_022650496.1 maltose O-acetyltransferase -
L1E13_RS18195 (L1E13_18195) 3837466..3837684 - 219 WP_015571250.1 HHA domain-containing protein Toxin
L1E13_RS18200 (L1E13_18200) 3837712..3838086 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
L1E13_RS18205 (L1E13_18205) 3838597..3841743 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
L1E13_RS18210 (L1E13_18210) 3841766..3842959 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T232120 WP_015571250.1 NZ_CP090909:c3837684-3837466 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T232120 NZ_CP127255:c4641100-4640948 [Escherichia coli]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT232120 WP_006809850.1 NZ_CP090909:c3838086-3837712 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT232120 NZ_CP127255:4641140-4641194 [Escherichia coli]
GTTTGGGTTCGAACGTAAGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References