Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1861733..1862390 Replicon chromosome
Accession NZ_CP090909
Organism Enterobacter hormaechei strain M1

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag L1E13_RS08835 Protein ID WP_022649305.1
Coordinates 1861733..1862143 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag L1E13_RS08840 Protein ID WP_003863437.1
Coordinates 1862124..1862390 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1E13_RS08815 (L1E13_08815) 1857731..1859464 - 1734 WP_023314793.1 single-stranded-DNA-specific exonuclease RecJ -
L1E13_RS08820 (L1E13_08820) 1859470..1860183 - 714 WP_234979350.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L1E13_RS08825 (L1E13_08825) 1860212..1861108 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
L1E13_RS08830 (L1E13_08830) 1861210..1861731 + 522 WP_003863440.1 flavodoxin FldB -
L1E13_RS08835 (L1E13_08835) 1861733..1862143 - 411 WP_022649305.1 protein YgfX Toxin
L1E13_RS08840 (L1E13_08840) 1862124..1862390 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
L1E13_RS08845 (L1E13_08845) 1862685..1863665 + 981 WP_063158748.1 tRNA-modifying protein YgfZ -
L1E13_RS08850 (L1E13_08850) 1863751..1864410 - 660 WP_023314797.1 hemolysin III family protein -
L1E13_RS08855 (L1E13_08855) 1864677..1865408 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
L1E13_RS08860 (L1E13_08860) 1865525..1866958 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T232117 WP_022649305.1 NZ_CP090909:c1862143-1861733 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T232117 NZ_CP127255:c3590832-3590730 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT232117 WP_003863437.1 NZ_CP090909:c1862390-1862124 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT232117 NZ_CP127255:3590692-3590960 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References