Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 406518..407257 Replicon chromosome
Accession NZ_CP090909
Organism Enterobacter hormaechei strain M1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag L1E13_RS01970 Protein ID WP_047055520.1
Coordinates 406518..407003 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag L1E13_RS01975 Protein ID WP_045336276.1
Coordinates 406991..407257 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1E13_RS01955 (L1E13_01955) 403073..403822 - 750 WP_234979040.1 hypothetical protein -
L1E13_RS01960 (L1E13_01960) 403815..405059 - 1245 WP_234979041.1 hypothetical protein -
L1E13_RS01965 (L1E13_01965) 405332..406036 - 705 Protein_390 IS3 family transposase -
L1E13_RS01970 (L1E13_01970) 406518..407003 - 486 WP_047055520.1 GNAT family N-acetyltransferase Toxin
L1E13_RS01975 (L1E13_01975) 406991..407257 - 267 WP_045336276.1 DUF1778 domain-containing protein Antitoxin
L1E13_RS01980 (L1E13_01980) 407321..408250 - 930 WP_234979042.1 LysR family transcriptional regulator -
L1E13_RS01985 (L1E13_01985) 408380..409768 + 1389 WP_048240775.1 MFS transporter -
L1E13_RS01990 (L1E13_01990) 409790..410785 - 996 WP_003857125.1 DUF2891 domain-containing protein -
L1E13_RS01995 (L1E13_01995) 410795..411781 - 987 WP_063159052.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T232107 WP_047055520.1 NZ_CP090909:c407003-406518 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLGEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T232107 NZ_CP127255:217198-217662 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAAACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT232107 WP_045336276.1 NZ_CP090909:c407257-406991 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT232107 NZ_CP127255:216863-217198 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References