Detailed information of TA system TA232104

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4415480..4416149
• Replicon: chromosome
• Accession: NZ_CP090908
• Organism: Serratia marcescens strain Sys06

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A0P0QIF8
• Locus tag: L1F17_RS21430
• Protein ID: WP_033632171.1
• Coordinates: 4415480..4415902 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: L1F17_RS21435
• Protein ID: WP_004931679.1
• Coordinates: 4415883..4416149 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1F17_RS21410 (L1F17_21410)	4411372..4411890	+	519	WP_004931683.1	flavodoxin FldB	-
L1F17_RS21415 (L1F17_21415)	4411925..4413289	-	1365	WP_060560181.1	cell envelope integrity protein CreD	-
L1F17_RS21420 (L1F17_21420)	4413370..4414788	-	1419	WP_033632173.1	two-component system sensor histidine kinase CreC	-
L1F17_RS21425 (L1F17_21425)	4414785..4415480	-	696	WP_033632172.1	two-component system response regulator CreB	-
L1F17_RS21430 (L1F17_21430)	4415480..4415902	-	423	WP_033632171.1	protein YgfX	Toxin
L1F17_RS21435 (L1F17_21435)	4415883..4416149	-	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
L1F17_RS21440 (L1F17_21440)	4416471..4417463	+	993	WP_033632169.1	tRNA-modifying protein YgfZ	-
L1F17_RS21445 (L1F17_21445)	4417502..4417999	-	498	WP_004931675.1	DUF2165 domain-containing protein	-
L1F17_RS21450 (L1F17_21450)	4418150..4418824	-	675	WP_033632168.1	hemolysin III family protein	-
L1F17_RS21455 (L1F17_21455)	4419008..4419616	+	609	WP_033632167.1	HD domain-containing protein	-
L1F17_RS21460 (L1F17_21460)	4419657..4420583	-	927	WP_015378971.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4408654..4478196	69542

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16518.60 Da
• Isoelectric Point: 10.8114

>T232104 WP_033632171.1 NZ_CP090908:c4415902-4415480 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEES

Nucleotide

• Length: 423 bp

>T232104 NZ_CP127254:c29623-29207 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT232104 WP_004931679.1 NZ_CP090908:c4416149-4415883 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT232104 NZ_CP127254:c29850-29620 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0P0QIF8