Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4033898..4034554 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name vapC Uniprot ID A0A086GBH4
Locus tag L1F17_RS19660 Protein ID WP_033632382.1
Coordinates 4033898..4034287 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086GBH3
Locus tag L1F17_RS19665 Protein ID WP_033632381.1
Coordinates 4034291..4034554 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS19645 (L1F17_19645) 4030365..4031795 + 1431 WP_060560043.1 multidrug transporter subunit MdtD -
L1F17_RS19650 (L1F17_19650) 4031792..4033174 + 1383 WP_060560044.1 two-component system sensor histidine kinase BaeS -
L1F17_RS19655 (L1F17_19655) 4033174..4033890 + 717 WP_004941568.1 two-component system response regulator BaeR -
L1F17_RS19660 (L1F17_19660) 4033898..4034287 - 390 WP_033632382.1 type II toxin-antitoxin system VapC family toxin Toxin
L1F17_RS19665 (L1F17_19665) 4034291..4034554 - 264 WP_033632381.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L1F17_RS19670 (L1F17_19670) 4034892..4035230 + 339 WP_004941561.1 YegP family protein -
L1F17_RS19675 (L1F17_19675) 4035409..4036761 + 1353 WP_060560045.1 tRNA 5-hydroxyuridine modification protein YegQ -
L1F17_RS19680 (L1F17_19680) 4037231..4038136 + 906 WP_044030681.1 lipid kinase YegS -
L1F17_RS19685 (L1F17_19685) 4038306..4039520 + 1215 WP_060560046.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14353.58 Da        Isoelectric Point: 8.4983

>T232102 WP_033632382.1 NZ_CP090908:c4034287-4033898 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRSKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKILGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T232102 NZ_CP127254:c4196-3798 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGGTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCTTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10089.34 Da        Isoelectric Point: 4.6702

>AT232102 WP_033632381.1 NZ_CP090908:c4034554-4034291 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLNIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT232102 NZ_CP127254:c4423-4196 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086GBH4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GBH3

References