Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 4033898..4034554 | Replicon | chromosome |
Accession | NZ_CP090908 | ||
Organism | Serratia marcescens strain Sys06 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A086GBH4 |
Locus tag | L1F17_RS19660 | Protein ID | WP_033632382.1 |
Coordinates | 4033898..4034287 (-) | Length | 130 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A086GBH3 |
Locus tag | L1F17_RS19665 | Protein ID | WP_033632381.1 |
Coordinates | 4034291..4034554 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L1F17_RS19645 (L1F17_19645) | 4030365..4031795 | + | 1431 | WP_060560043.1 | multidrug transporter subunit MdtD | - |
L1F17_RS19650 (L1F17_19650) | 4031792..4033174 | + | 1383 | WP_060560044.1 | two-component system sensor histidine kinase BaeS | - |
L1F17_RS19655 (L1F17_19655) | 4033174..4033890 | + | 717 | WP_004941568.1 | two-component system response regulator BaeR | - |
L1F17_RS19660 (L1F17_19660) | 4033898..4034287 | - | 390 | WP_033632382.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
L1F17_RS19665 (L1F17_19665) | 4034291..4034554 | - | 264 | WP_033632381.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
L1F17_RS19670 (L1F17_19670) | 4034892..4035230 | + | 339 | WP_004941561.1 | YegP family protein | - |
L1F17_RS19675 (L1F17_19675) | 4035409..4036761 | + | 1353 | WP_060560045.1 | tRNA 5-hydroxyuridine modification protein YegQ | - |
L1F17_RS19680 (L1F17_19680) | 4037231..4038136 | + | 906 | WP_044030681.1 | lipid kinase YegS | - |
L1F17_RS19685 (L1F17_19685) | 4038306..4039520 | + | 1215 | WP_060560046.1 | D-galactonate dehydratase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 130 a.a. Molecular weight: 14353.58 Da Isoelectric Point: 8.4983
>T232102 WP_033632382.1 NZ_CP090908:c4034287-4033898 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRSKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKILGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRSKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKILGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR
Download Length: 390 bp
>T232102 NZ_CP127254:c4196-3798 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGGTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCTTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGGTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCTTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10089.34 Da Isoelectric Point: 4.6702
>AT232102 WP_033632381.1 NZ_CP090908:c4034554-4034291 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLNIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLNIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE
Download Length: 264 bp
>AT232102 NZ_CP127254:c4423-4196 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A086GBH4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A086GBH3 |