Detailed information of TA system TA232100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3478526..3479121
• Replicon: chromosome
• Accession: NZ_CP090908
• Organism: Serratia marcescens strain Sys06

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: L1F17_RS16810
• Protein ID: WP_071605322.1
• Coordinates: 3478867..3479121 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: L1F17_RS16805
• Protein ID: WP_021505859.1
• Coordinates: 3478526..3478870 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1F17_RS16785 (L1F17_16785)	3473616..3476705	+	3090	WP_060559879.1	beta-galactosidase	-
L1F17_RS16795 (L1F17_16795)	3476972..3477236	+	265	Protein_3276	Presumed portal vertex protein	-
L1F17_RS16800 (L1F17_16800)	3477270..3478481	-	1212	WP_079007630.1	FRG domain-containing protein	-
L1F17_RS16805 (L1F17_16805)	3478526..3478870	-	345	WP_021505859.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L1F17_RS16810 (L1F17_16810)	3478867..3479121	-	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
L1F17_RS16815 (L1F17_16815)	3479803..3481509	+	1707	WP_033632620.1	hypothetical protein	-
L1F17_RS16820 (L1F17_16820)	3481560..3482132	-	573	WP_060559880.1	hypothetical protein	-
L1F17_RS16825 (L1F17_16825)	3482261..3483151	+	891	WP_033632618.1	LysR substrate-binding domain-containing protein	-
L1F17_RS16830 (L1F17_16830)	3483105..3483842	-	738	WP_139806250.1	autoinducer binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (56-101)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T232100 WP_071605322.1 NZ_CP090908:c3479121-3478867 [Serratia marcescens]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T232100 NZ_CP127252:4696125-4696502 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CCACTACAGAACGGTAAATGACATTACCCTGGGTAAACGTACGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12464.05 Da
• Isoelectric Point: 4.5562

>AT232100 WP_021505859.1 NZ_CP090908:c3478870-3478526 [Serratia marcescens]
MMNNTLKIGGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGALSLAVFLDECQKDGIEPYKSYSGKVTTRLS
PERHQALALAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 345 bp

>AT232100 NZ_CP127252:4695701-4696078 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCAGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGTCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1