Detailed information of TA system TA232099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3186560..3187191
• Replicon: chromosome
• Accession: NZ_CP090908
• Organism: Serratia marcescens strain Sys06

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L1F17_RS15410
• Protein ID: WP_019452963.1
• Coordinates: 3186560..3186958 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A086GDB9
• Locus tag: L1F17_RS15415
• Protein ID: WP_004934853.1
• Coordinates: 3186958..3187191 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1F17_RS15385 (L1F17_15385)	3182131..3182502	+	372	WP_048324006.1	type II toxin-antitoxin system RelE/ParE family toxin	-
L1F17_RS15390 (L1F17_15390)	3182499..3182801	+	303	WP_033632742.1	DNA-binding transcriptional regulator	-
L1F17_RS15395 (L1F17_15395)	3182804..3183208	-	405	WP_060559818.1	flagellar protein FlhE	-
L1F17_RS15400 (L1F17_15400)	3183208..3185286	-	2079	WP_033632740.1	flagellar biosynthesis protein FlhA	-
L1F17_RS15405 (L1F17_15405)	3185279..3186430	-	1152	WP_021504091.1	flagellar biosynthesis protein FlhB	-
L1F17_RS15410 (L1F17_15410)	3186560..3186958	-	399	WP_019452963.1	type II toxin-antitoxin system VapC family toxin	Toxin
L1F17_RS15415 (L1F17_15415)	3186958..3187191	-	234	WP_004934853.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L1F17_RS15420 (L1F17_15420)	3187317..3187961	-	645	WP_004934858.1	protein phosphatase CheZ	-
L1F17_RS15425 (L1F17_15425)	3187972..3188361	-	390	WP_004934862.1	chemotaxis response regulator CheY	-
L1F17_RS15430 (L1F17_15430)	3188464..3189513	-	1050	WP_049277000.1	chemotaxis response regulator protein-glutamate methylesterase	-
L1F17_RS15435 (L1F17_15435)	3189513..3190385	-	873	WP_025159837.1	protein-glutamate O-methyltransferase CheR	-
L1F17_RS15440 (L1F17_15440)	3190414..3192039	-	1626	WP_004934871.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-45)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14876.02 Da
• Isoelectric Point: 8.4955

>T232099 WP_019452963.1 NZ_CP090908:c3186958-3186560 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSVTYGELVHGVEKSSRPAVNARVVEDFVSRLDILDYGAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVDGLRLENWL

Nucleotide

• Length: 399 bp

>T232099 NZ_CP127252:c4544180-4543773 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCTCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8837.86 Da
• Isoelectric Point: 4.7954

>AT232099 WP_004934853.1 NZ_CP090908:c3187191-3186958 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPVENTWDSFFCAENEVSDDFLNERAGQHQREREEL

Nucleotide

• Length: 234 bp

>AT232099 NZ_CP127252:c4544427-4544161 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A086GDB9