Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3144658..3145286 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name hicA Uniprot ID A0A0P0QK57
Locus tag L1F17_RS15160 Protein ID WP_015378230.1
Coordinates 3144658..3144861 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A086GDG8
Locus tag L1F17_RS15165 Protein ID WP_015378231.1
Coordinates 3144873..3145286 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS15155 (L1F17_15155) 3140523..3144494 + 3972 WP_060559807.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
L1F17_RS15160 (L1F17_15160) 3144658..3144861 + 204 WP_015378230.1 type II toxin-antitoxin system HicA family toxin Toxin
L1F17_RS15165 (L1F17_15165) 3144873..3145286 + 414 WP_015378231.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L1F17_RS15170 (L1F17_15170) 3145316..3146068 - 753 WP_033632770.1 L-cystine ABC transporter ATP-binding protein TcyN -
L1F17_RS15175 (L1F17_15175) 3146072..3146734 - 663 WP_015378233.1 cystine ABC transporter permease -
L1F17_RS15180 (L1F17_15180) 3146734..3147534 - 801 WP_015378234.1 cystine ABC transporter substrate-binding protein -
L1F17_RS15185 (L1F17_15185) 3147650..3148642 - 993 WP_060559808.1 D-cysteine desulfhydrase -
L1F17_RS15190 (L1F17_15190) 3148767..3149276 - 510 WP_004934751.1 flagella biosynthesis regulatory protein FliZ -
L1F17_RS15195 (L1F17_15195) 3149331..3150053 - 723 WP_004934752.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7523.89 Da        Isoelectric Point: 11.1475

>T232098 WP_015378230.1 NZ_CP090908:3144658-3144861 [Serratia marcescens]
VKSSELIALLESHGWVLRRVKGSHHQFKHPDFALIITVPHPKKDLKLGTLRQILKDAGLSALHIATR

Download         Length: 204 bp

>T232098 NZ_CP127252:c4407683-4407348 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14888.63 Da        Isoelectric Point: 5.4867

>AT232098 WP_015378231.1 NZ_CP090908:3144873-3145286 [Serratia marcescens]
MFYPAYIHTESNGSASGFFPDVPGCYFAGTSLDDAFADAQSALDAHFELLSEDNQPLPRPHAVAAHLAKDAGSFEGGQWL
LVAINMDKFDGRAERINITLPHRLLSRIDSLVRQHPGYGSRSGFLAAAARNELLKAE

Download         Length: 414 bp

>AT232098 NZ_CP127252:c4407931-4407683 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QK57

Antitoxin

Source ID Structure
AlphaFold DB A0A086GDG8

References