Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 3144658..3145286 | Replicon | chromosome |
Accession | NZ_CP090908 | ||
Organism | Serratia marcescens strain Sys06 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A0P0QK57 |
Locus tag | L1F17_RS15160 | Protein ID | WP_015378230.1 |
Coordinates | 3144658..3144861 (+) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A086GDG8 |
Locus tag | L1F17_RS15165 | Protein ID | WP_015378231.1 |
Coordinates | 3144873..3145286 (+) | Length | 138 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L1F17_RS15155 (L1F17_15155) | 3140523..3144494 | + | 3972 | WP_060559807.1 | trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase | - |
L1F17_RS15160 (L1F17_15160) | 3144658..3144861 | + | 204 | WP_015378230.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
L1F17_RS15165 (L1F17_15165) | 3144873..3145286 | + | 414 | WP_015378231.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
L1F17_RS15170 (L1F17_15170) | 3145316..3146068 | - | 753 | WP_033632770.1 | L-cystine ABC transporter ATP-binding protein TcyN | - |
L1F17_RS15175 (L1F17_15175) | 3146072..3146734 | - | 663 | WP_015378233.1 | cystine ABC transporter permease | - |
L1F17_RS15180 (L1F17_15180) | 3146734..3147534 | - | 801 | WP_015378234.1 | cystine ABC transporter substrate-binding protein | - |
L1F17_RS15185 (L1F17_15185) | 3147650..3148642 | - | 993 | WP_060559808.1 | D-cysteine desulfhydrase | - |
L1F17_RS15190 (L1F17_15190) | 3148767..3149276 | - | 510 | WP_004934751.1 | flagella biosynthesis regulatory protein FliZ | - |
L1F17_RS15195 (L1F17_15195) | 3149331..3150053 | - | 723 | WP_004934752.1 | RNA polymerase sigma factor FliA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 7523.89 Da Isoelectric Point: 11.1475
>T232098 WP_015378230.1 NZ_CP090908:3144658-3144861 [Serratia marcescens]
VKSSELIALLESHGWVLRRVKGSHHQFKHPDFALIITVPHPKKDLKLGTLRQILKDAGLSALHIATR
VKSSELIALLESHGWVLRRVKGSHHQFKHPDFALIITVPHPKKDLKLGTLRQILKDAGLSALHIATR
Download Length: 204 bp
>T232098 NZ_CP127252:c4407683-4407348 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 138 a.a. Molecular weight: 14888.63 Da Isoelectric Point: 5.4867
>AT232098 WP_015378231.1 NZ_CP090908:3144873-3145286 [Serratia marcescens]
MFYPAYIHTESNGSASGFFPDVPGCYFAGTSLDDAFADAQSALDAHFELLSEDNQPLPRPHAVAAHLAKDAGSFEGGQWL
LVAINMDKFDGRAERINITLPHRLLSRIDSLVRQHPGYGSRSGFLAAAARNELLKAE
MFYPAYIHTESNGSASGFFPDVPGCYFAGTSLDDAFADAQSALDAHFELLSEDNQPLPRPHAVAAHLAKDAGSFEGGQWL
LVAINMDKFDGRAERINITLPHRLLSRIDSLVRQHPGYGSRSGFLAAAARNELLKAE
Download Length: 414 bp
>AT232098 NZ_CP127252:c4407931-4407683 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0P0QK57 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A086GDG8 |