Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1747086..1747611 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name relE Uniprot ID A0A0N7JPE4
Locus tag L1F17_RS08310 Protein ID WP_060559116.1
Coordinates 1747086..1747370 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag L1F17_RS08315 Protein ID WP_004928423.1
Coordinates 1747360..1747611 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS08285 (L1F17_08285) 1742348..1743481 + 1134 WP_004938650.1 putrescine ABC transporter ATP-binding subunit PotG -
L1F17_RS08290 (L1F17_08290) 1743506..1744468 + 963 WP_033633472.1 putrescine ABC transporter permease PotH -
L1F17_RS08295 (L1F17_08295) 1744465..1745310 + 846 WP_004938644.1 putrescine ABC transporter permease PotI -
L1F17_RS08300 (L1F17_08300) 1745415..1745900 + 486 WP_050501266.1 YbjO family protein -
L1F17_RS08305 (L1F17_08305) 1745962..1747089 + 1128 WP_060559114.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
L1F17_RS08310 (L1F17_08310) 1747086..1747370 - 285 WP_060559116.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1F17_RS08315 (L1F17_08315) 1747360..1747611 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
L1F17_RS08320 (L1F17_08320) 1747713..1748447 - 735 WP_015377297.1 arginine ABC transporter substrate-binding protein -
L1F17_RS08325 (L1F17_08325) 1748647..1749315 - 669 WP_004928418.1 arginine ABC transporter permease ArtM -
L1F17_RS08330 (L1F17_08330) 1749315..1750031 - 717 WP_004928413.1 arginine ABC transporter permease ArtQ -
L1F17_RS08335 (L1F17_08335) 1750041..1750772 - 732 WP_060559118.1 arginine ABC transporter substrate-binding protein -
L1F17_RS08340 (L1F17_08340) 1750805..1751533 - 729 WP_004928406.1 arginine ABC transporter ATP-binding protein ArtP -
L1F17_RS08345 (L1F17_08345) 1751796..1752338 - 543 WP_015377301.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10803.94 Da        Isoelectric Point: 10.6941

>T232089 WP_060559116.1 NZ_CP090908:c1747370-1747086 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRIMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T232089 NZ_CP127252:c2665238-2665131 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT232089 WP_004928423.1 NZ_CP090908:c1747611-1747360 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT232089 NZ_CP127252:2665291-2665352 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N7JPE4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References