Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 1616318..1616865 | Replicon | chromosome |
| Accession | NZ_CP090908 | ||
| Organism | Serratia marcescens strain Sys06 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A086G3V8 |
| Locus tag | L1F17_RS07735 | Protein ID | WP_033633716.1 |
| Coordinates | 1616557..1616865 (+) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A0G3SUU9 |
| Locus tag | L1F17_RS07730 | Protein ID | WP_033633717.1 |
| Coordinates | 1616318..1616554 (+) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1F17_RS07715 (L1F17_07715) | 1612804..1614339 | + | 1536 | WP_060559031.1 | glutathione ABC transporter substrate-binding protein GsiB | - |
| L1F17_RS07720 (L1F17_07720) | 1614392..1615312 | + | 921 | WP_060559032.1 | glutathione ABC transporter permease GsiC | - |
| L1F17_RS07725 (L1F17_07725) | 1615322..1616230 | + | 909 | WP_019454428.1 | glutathione ABC transporter permease GsiD | - |
| L1F17_RS07730 (L1F17_07730) | 1616318..1616554 | + | 237 | WP_033633717.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| L1F17_RS07735 (L1F17_07735) | 1616557..1616865 | + | 309 | WP_033633716.1 | CcdB family protein | Toxin |
| L1F17_RS07740 (L1F17_07740) | 1616902..1617744 | - | 843 | WP_015377214.1 | S-formylglutathione hydrolase | - |
| L1F17_RS07745 (L1F17_07745) | 1617759..1618883 | - | 1125 | WP_015377215.1 | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase | - |
| L1F17_RS07750 (L1F17_07750) | 1618913..1619833 | - | 921 | WP_004938975.1 | LysR family transcriptional regulator | - |
| L1F17_RS07755 (L1F17_07755) | 1619939..1621096 | + | 1158 | WP_031299819.1 | YbfB/YjiJ family MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11448.21 Da Isoelectric Point: 5.0196
>T232088 WP_033633716.1 NZ_CP090908:1616557-1616865 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQLGKA
VGNANEHRNQIKAAIDFLIDGF
MQFTVYDNTYPASAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQLGKA
VGNANEHRNQIKAAIDFLIDGF
Download Length: 309 bp
>T232088 NZ_CP127252:c2664703-2664596 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8994.07 Da Isoelectric Point: 5.0807
>AT232088 WP_033633717.1 NZ_CP090908:1616318-1616554 [Serratia marcescens]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF
Download Length: 237 bp
>AT232088 NZ_CP127252:2664751-2664817 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A086G3V8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0G3SUU9 |