Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1616318..1616865 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name ccdB Uniprot ID A0A086G3V8
Locus tag L1F17_RS07735 Protein ID WP_033633716.1
Coordinates 1616557..1616865 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag L1F17_RS07730 Protein ID WP_033633717.1
Coordinates 1616318..1616554 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS07715 (L1F17_07715) 1612804..1614339 + 1536 WP_060559031.1 glutathione ABC transporter substrate-binding protein GsiB -
L1F17_RS07720 (L1F17_07720) 1614392..1615312 + 921 WP_060559032.1 glutathione ABC transporter permease GsiC -
L1F17_RS07725 (L1F17_07725) 1615322..1616230 + 909 WP_019454428.1 glutathione ABC transporter permease GsiD -
L1F17_RS07730 (L1F17_07730) 1616318..1616554 + 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
L1F17_RS07735 (L1F17_07735) 1616557..1616865 + 309 WP_033633716.1 CcdB family protein Toxin
L1F17_RS07740 (L1F17_07740) 1616902..1617744 - 843 WP_015377214.1 S-formylglutathione hydrolase -
L1F17_RS07745 (L1F17_07745) 1617759..1618883 - 1125 WP_015377215.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
L1F17_RS07750 (L1F17_07750) 1618913..1619833 - 921 WP_004938975.1 LysR family transcriptional regulator -
L1F17_RS07755 (L1F17_07755) 1619939..1621096 + 1158 WP_031299819.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11448.21 Da        Isoelectric Point: 5.0196

>T232088 WP_033633716.1 NZ_CP090908:1616557-1616865 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQLGKA
VGNANEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T232088 NZ_CP127252:c2664703-2664596 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT232088 WP_033633717.1 NZ_CP090908:1616318-1616554 [Serratia marcescens]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT232088 NZ_CP127252:2664751-2664817 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086G3V8

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References