Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1117206..1117827 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag L1F17_RS05265 Protein ID WP_004940313.1
Coordinates 1117206..1117409 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag L1F17_RS05270 Protein ID WP_004940312.1
Coordinates 1117459..1117827 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS05245 (L1F17_05245) 1112724..1114094 + 1371 WP_033633990.1 amidase -
L1F17_RS05250 (L1F17_05250) 1114145..1116085 - 1941 WP_033633989.1 NAD(P)/FAD-dependent oxidoreductase -
L1F17_RS05255 (L1F17_05255) 1116415..1116690 + 276 WP_050501286.1 hypothetical protein -
L1F17_RS05260 (L1F17_05260) 1116742..1116939 + 198 WP_050501285.1 cytochrome b/b6 domain-containing protein -
L1F17_RS05265 (L1F17_05265) 1117206..1117409 - 204 WP_004940313.1 HHA domain-containing protein Toxin
L1F17_RS05270 (L1F17_05270) 1117459..1117827 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
L1F17_RS05275 (L1F17_05275) 1117986..1118339 - 354 WP_004940311.1 hypothetical protein -
L1F17_RS05280 (L1F17_05280) 1118744..1119457 + 714 WP_060560414.1 ABC transporter ATP-binding protein -
L1F17_RS05285 (L1F17_05285) 1119454..1120311 + 858 WP_033633988.1 metal ABC transporter permease -
L1F17_RS05290 (L1F17_05290) 1120336..1121214 + 879 WP_021504668.1 metal ABC transporter substrate-binding protein -
L1F17_RS05295 (L1F17_05295) 1121323..1121463 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
L1F17_RS05300 (L1F17_05300) 1121476..1121730 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T232087 WP_004940313.1 NZ_CP090908:c1117409-1117206 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T232087 NZ_CP127252:c1787688-1787470 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT232087 WP_004940312.1 NZ_CP090908:c1117827-1117459 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT232087 NZ_CP127252:c1788088-1787714 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References