Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1117206..1117827 | Replicon | chromosome |
Accession | NZ_CP090908 | ||
Organism | Serratia marcescens strain Sys06 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | A0A8B4G7F9 |
Locus tag | L1F17_RS05265 | Protein ID | WP_004940313.1 |
Coordinates | 1117206..1117409 (-) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | A0A2X2G5J9 |
Locus tag | L1F17_RS05270 | Protein ID | WP_004940312.1 |
Coordinates | 1117459..1117827 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L1F17_RS05245 (L1F17_05245) | 1112724..1114094 | + | 1371 | WP_033633990.1 | amidase | - |
L1F17_RS05250 (L1F17_05250) | 1114145..1116085 | - | 1941 | WP_033633989.1 | NAD(P)/FAD-dependent oxidoreductase | - |
L1F17_RS05255 (L1F17_05255) | 1116415..1116690 | + | 276 | WP_050501286.1 | hypothetical protein | - |
L1F17_RS05260 (L1F17_05260) | 1116742..1116939 | + | 198 | WP_050501285.1 | cytochrome b/b6 domain-containing protein | - |
L1F17_RS05265 (L1F17_05265) | 1117206..1117409 | - | 204 | WP_004940313.1 | HHA domain-containing protein | Toxin |
L1F17_RS05270 (L1F17_05270) | 1117459..1117827 | - | 369 | WP_004940312.1 | Hha toxicity modulator TomB | Antitoxin |
L1F17_RS05275 (L1F17_05275) | 1117986..1118339 | - | 354 | WP_004940311.1 | hypothetical protein | - |
L1F17_RS05280 (L1F17_05280) | 1118744..1119457 | + | 714 | WP_060560414.1 | ABC transporter ATP-binding protein | - |
L1F17_RS05285 (L1F17_05285) | 1119454..1120311 | + | 858 | WP_033633988.1 | metal ABC transporter permease | - |
L1F17_RS05290 (L1F17_05290) | 1120336..1121214 | + | 879 | WP_021504668.1 | metal ABC transporter substrate-binding protein | - |
L1F17_RS05295 (L1F17_05295) | 1121323..1121463 | - | 141 | WP_004940304.1 | type B 50S ribosomal protein L36 | - |
L1F17_RS05300 (L1F17_05300) | 1121476..1121730 | - | 255 | WP_004940303.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8107.37 Da Isoelectric Point: 6.9756
>T232087 WP_004940313.1 NZ_CP090908:c1117409-1117206 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR
Download Length: 204 bp
>T232087 NZ_CP127252:c1787688-1787470 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14261.95 Da Isoelectric Point: 4.4314
>AT232087 WP_004940312.1 NZ_CP090908:c1117827-1117459 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT
Download Length: 369 bp
>AT232087 NZ_CP127252:c1788088-1787714 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B4G7F9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2X2G5J9 |