Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 502551..503122 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name relE Uniprot ID A0A0N7JP08
Locus tag L1F17_RS02355 Protein ID WP_048325889.1
Coordinates 502847..503122 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag L1F17_RS02350 Protein ID WP_013811307.1
Coordinates 502551..502838 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS02325 (L1F17_02325) 498320..499405 - 1086 WP_060558428.1 carbon-phosphorus lyase complex subunit PhnI -
L1F17_RS02330 (L1F17_02330) 499405..499986 - 582 WP_060558429.1 phosphonate C-P lyase system protein PhnH -
L1F17_RS02335 (L1F17_02335) 499990..500433 - 444 WP_033631646.1 phosphonate C-P lyase system protein PhnG -
L1F17_RS02340 (L1F17_02340) 500434..501162 - 729 WP_048325886.1 phosphonate metabolism transcriptional regulator PhnF -
L1F17_RS02345 (L1F17_02345) 501390..502445 + 1056 WP_060558431.1 permease -
L1F17_RS02350 (L1F17_02350) 502551..502838 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L1F17_RS02355 (L1F17_02355) 502847..503122 + 276 WP_048325889.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
L1F17_RS02360 (L1F17_02360) 503128..503592 - 465 WP_060558433.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L1F17_RS02365 (L1F17_02365) 503761..505899 - 2139 WP_060558435.1 anaerobic ribonucleoside-triphosphate reductase -
L1F17_RS02370 (L1F17_02370) 506144..507058 - 915 WP_060558437.1 LysR family transcriptional regulator -
L1F17_RS02375 (L1F17_02375) 507164..507688 + 525 WP_033631652.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10722.49 Da        Isoelectric Point: 9.5103

>T232086 WP_048325889.1 NZ_CP090908:502847-503122 [Serratia marcescens]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLDHPELGKPWYGKARKLLVNKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

>T232086 NZ_CP127252:c1753716-1753174 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT232086 WP_013811307.1 NZ_CP090908:502551-502838 [Serratia marcescens]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT232086 NZ_CP127252:c1754011-1753700 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N7JP08

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References