Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 55034..55569 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name relE Uniprot ID A0A086G6D5
Locus tag L1F17_RS00250 Protein ID WP_033631416.1
Coordinates 55294..55569 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G6D4
Locus tag L1F17_RS00245 Protein ID WP_033631415.1
Coordinates 55034..55294 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS00225 (L1F17_00225) 50358..51008 + 651 WP_060558038.1 DcrB-related protein -
L1F17_RS00230 (L1F17_00230) 51044..51649 + 606 WP_060558041.1 glutathione S-transferase -
L1F17_RS00235 (L1F17_00235) 51719..53113 + 1395 WP_060558042.1 L-seryl-tRNA(Sec) selenium transferase -
L1F17_RS00240 (L1F17_00240) 53110..54951 + 1842 WP_060558044.1 selenocysteine-specific translation elongation factor -
L1F17_RS00245 (L1F17_00245) 55034..55294 + 261 WP_033631415.1 ribbon-helix-helix domain-containing protein Antitoxin
L1F17_RS00250 (L1F17_00250) 55294..55569 + 276 WP_033631416.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1F17_RS00255 (L1F17_00255) 55581..56492 - 912 WP_060558046.1 LysR family transcriptional regulator -
L1F17_RS00260 (L1F17_00260) 56614..57240 + 627 WP_033631418.1 LysE family translocator -
L1F17_RS00265 (L1F17_00265) 57294..58541 - 1248 WP_033633516.1 MFS transporter -
L1F17_RS00270 (L1F17_00270) 58759..59751 + 993 WP_060558048.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.30 Da        Isoelectric Point: 10.3377

>T232084 WP_033631416.1 NZ_CP090908:55294-55569 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPAAIY
VLRIWHTREER

Download         Length: 276 bp

>T232084 NZ_CP127252:1029829-1030179 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9712.03 Da        Isoelectric Point: 4.5317

>AT232084 WP_033631415.1 NZ_CP090908:55034-55294 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Download         Length: 261 bp

>AT232084 NZ_CP127252:1029584-1029835 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086G6D5

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6D4

References